Sicong Wang

A Dynamic Stem Cell State Links Environmental Cues to Skeletal and Regenerative Fates

The paper identifies a dynamic stem cell state marked by Panx3 that responds to environmental cues and enables regeneration in aged and osteoarthritic joints.

The endo-lysosomal system drives lumen formation in a human epiblast model

This study identifies RAB35's role in regulating endo-lysosomal dynamics during apicosome formation in a human epiblast model.

Xenophagocytosis blockade enhances interspecies chimerism

This study identifies xenophagocytosis as an innate immune barrier that limits interspecies chimerism and shows that blocking it enhances donor cell engraftment in mouse embryos.

Optimized protocol for processing murine tumor-bearing lung tissue for flow cytometry and single cell RNA-sequencing

The paper presents a protocol for isolating high-quality single-cell suspensions from murine lung tissue for scRNA-seq and flow cytometry.

A human-specific regulatory mechanism revealed in a preimplantation model

The paper investigates the role of HERVK LTR5Hs elements in human preimplantation development, showing their cis-regulatory impact on the epiblast transcriptome and their essential role in blastoid formation through ZNF729 activation.

Secreted Particle Information Transfer (SPIT) - A Cellular Platform For In Vivo Genetic Engineering

The paper introduces SPIT, a method using human cells to deliver genetic tools in vivo, demonstrating its application for modifying multiple organs and tissues in immunocompetent mice.