Thomas H. Ambrosi

A Dynamic Stem Cell State Links Environmental Cues to Skeletal and Regenerative Fates

The paper identifies a dynamic stem cell state marked by Panx3 that responds to environmental cues and enables regeneration in aged and osteoarthritic joints.

Bioorthogonal Tethering of FGF18 to Annealed Microgel Scaffolds Enhances Cartilage Repair

This paper develops FGF18-tethered microgel scaffolds to enhance cartilage repair by optimizing surface charge and growth factor presentation.

Basigin Links Altered Skeletal Stem Cell Lineage Dynamics with Glucocorticoid-induced Bone Loss and Impaired Angiogenesis

This study identifies Basigin's role in GC-induced bone loss and impaired angiogenesis by linking altered skeletal stem cell dynamics to vascular dysfunction, showing that anti-Basigin therapy can reverse these effects.

Brain-Derived CCN3 Is An Osteoanabolic Hormone That Sustains Bone in Lactating Females

This paper identifies CCN3 as a brain-derived hormone that promotes bone mass in lactating females by compensating for estrogen loss and supporting skeletal stem cells.

Adversarial domain translation networks for fast and accurate integration of large-scale atlas-level single-cell datasets

Portal integrates large-scale single-cell datasets efficiently and accurately by preserving biological variation across samples, platforms, and species.