Makoto Matsuyama

Characterization of a maintainable human myeloid model of VEXAS syndrome with enhanced TNF-induced cell death and DAMP release

This study creates a human myeloid cell model of VEXAS syndrome with UBA1 mutations, showing increased TNF-induced cell death and DAMP release.

Cellular fitness is determined by ribosomal protein S12-mediated release of a truncated Xrp1

The paper identifies a post-transcriptional mechanism where ribosomal protein S12 regulates Xrp1 expression through alternative splicing, leading to cell death in unfit cells.

Emergence of cell polarity by reciprocal interactions between Wnt and core PCP components

This study shows that Wnt11 and core PCP components interact reciprocally to establish cell polarity in Xenopus embryos without relying on Wnt gradients.

Development of a sandwich ELISA for the detection of bovine A1 beta-casein

This paper develops a sandwich ELISA to detect A1 beta-casein in A2 milk, showing it can identify contamination at 1% A1 spike in a herd of A2A2 cows.

Dynamic polarization of heparan sulfate proteoglycans is involved in planar cell polarity and localization of endogenous Wnt11 during vertebrate neural tube formation.

The paper shows that heparan sulfate proteoglycans (HSPGs) are dynamically polarized during vertebrate neural tube formation, interacting with Wnt11 and core PCP components to establish planar cell polarity.

Trim41 is essential for preventing X chromosome chaotic synapsis in male mice

This study shows that Trim41 prevents chaotic X chromosome synapsis in male mice, leading to infertility when disrupted.

KCTD19 associates with ZFP541 and HDAC1 and is required for meiotic exit in male mice

The paper identifies KCTD19 as essential for meiotic exit in male mice, showing it interacts with ZFP541 and HDAC1, and its deficiency causes apoptosis during meiosis.

Ectopic expression induces abnormal somatodendritic distribution of tau in the mouse brain

This study shows that ectopic expression of human tau in mice leads to abnormal somatodendritic distribution, while knock-in mice show normal axonal localization due to developmental expression patterns.

In situ genome editing method suitable for routine generation of germline modified animal models

This paper improves the GONAD method for in situ genome editing, achieving efficiency comparable to microinjection for generating germline modified animal models.