bioRxivPharmacology & ToxicologyPreprint
Development of Narrow Spectrum ATP-competitive Kinase Inhibitors as Probes for BIKE and AAK1
Rafael M. Couñago, Alison D. Axtman, Stephen J. Capuzzi, Hátylas Azevedo, David H. Drewry, Jonathan M. Elkins, Opher Gileadi, Cristiano R. W. Guimarães, Alessandra Mascarello, Ricardo A. M. Serafim, Carrow I. Wells, Timothy M. Willson, William J. ZuercheriD
Abstract
Understanding the structural determinants of inhibitor selectivity would facilitate the design and preparation of kinase probes. We describe a pair of matched compounds differing only by one degree of saturation but showing dramatic differential activities at select kinases. We utilized x-ray crystallography and computational analysis to rationalize the basis of the differential activity.
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