bioRxivMicrobiology
Novel quinolone resistance determinant, qepA8, in Shigella flexneri isolated in the United States, 2016
H. E. Webb, K. A. Tagg, J. C. Chen, J. Kim, R. L. Lindsey, L. Francois Watkins, B. E. Karp, Y. Sugawara, J. P. Folster
Abstract
A qepA8+ Shigella flexneri was cultured from the stool of a traveler returning from India and East Asia. This chromosomally encoded qepA variant, has a six-base insertion, and may have been mobilized as part of a complex IS1-mediated composite transposon including catA1, aadA1, and blaOXA-1. In laboratory E. coli, qepA8 alone only conferred decreased ciprofloxacin susceptibility; however, it may work in combination with additional mechanisms to confer clinical resistance.
- organism: bacteria (other)
- research focus: host-pathogen & immune response
- approach: experimental assay
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