S. Baker

Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation.

The paper identifies Mgl2+ cDC2s as key drivers of type 2, but not type 17, fungal allergic airway inflammation in mice.

Shigella serotypes associated with carriage in humans establish persistent infection in zebrafish

This paper shows that three Shigella serotypes associated with MSM transmission can establish persistent infection in zebrafish, failing to promote macrophage cell death.

The origins of haplotype 58 (H58) Salmonella enterica serovar Typhi

This study traces the origin and spread of the H58 lineage of Salmonella Typhi, showing it emerged in India in 1987 as multi-drug resistant and later became globally prevalent.

We the Hunted

The paper reclassifies the SK 54 cranium as Homo erectus, challenging the hypothesis that Homo was better at avoiding predation than Paranthropus.

Perspectives of pharmacy employees on an inappropriate use of antimicrobials in Kathmandu, Nepal

This study examines pharmacy employees' knowledge, attitudes, and practices regarding antimicrobial dispensing in Nepal, finding widespread inappropriate use and awareness of antimicrobial resistance.

Mucosal microbiomes and Fusobacterium genomics in Vietnamese colorectal cancer patients

This study examines the mucosal microbiome and Fusobacterium genomics in Vietnamese colorectal cancer patients, finding increased abundance of oral bacteria in tumors and genomic diversity within Fusobacterium species.

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

The paper develops a sensitive cell-based luciferase assay for high-throughput screening of SARS-CoV-2 nsp5/3CLpro inhibitors and identifies four effective compounds.

Poly (acetyl arginyl) glucosamine attenuates Pseudomonas aeruginosa in a rat lung infection model

This study evaluates PAAG's effect on P. aeruginosa biofilms and lung infections in rats, finding it reduces bacterial biomass and inflammation.

H3-K27M-Mutant Nucleosomes Interact with MLL1 to Shape the Glioma Epigenetic Landscape

This study shows H3-K27M mutations alter chromatin marks by affecting PRC2 and MLL1 interactions, leading to bivalent chromatin and supporting glioma development.

FXR inhibition reduces ACE2 expression, SARS-CoV-2 infection and may improve COVID-19 outcome

This study shows FXR inhibition lowers ACE2 expression, reduces SARS-CoV-2 infection, and correlates with better clinical outcomes in COVID-19.

Inhibitory concentrations of ciprofloxacin induce an adaptive response promoting the intracellular survival of Salmonella Typhimurium

This study shows that inhibitory concentrations of ciprofloxacin induce adaptive responses in Salmonella Typhimurium that enhance intracellular survival and replication.

Exploring the genomic diversity and antimicrobial susceptibility of Bifidobacterium pseudocatenulatum in the Vietnamese population to aid probiotic design

The paper characterizes the genomic diversity and antimicrobial resistance of Bifidobacterium pseudocatenulatum in Vietnamese individuals to guide probiotic development.

High-content imaging to phenotype antimicrobial effects on individual bacteria at scale

This paper develops a high-throughput high-content imaging method to phenotype bacterial responses to antimicrobials, revealing morphological differences between susceptible and resistant isolates.

Global population structure and genotyping framework for genomic surveillance of the major dysentery pathogen, Shigella sonnei

The paper develops a genomic framework and genotyping scheme for Shigella sonnei to identify resistance determinants from WGS data, revealing common genotypes linked to antimicrobial resistance and global spread.

Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the colon

This study investigates Ca2+ signaling in submucosal interstitial cells of Cajal (ICC-SM) and its role in driving smooth muscle contractions in the colon.

A novel method for measuring phenotypic colistin resistance in Escherichia coli populations from chicken flocks

This paper develops and validates a growth-based microdilution method to measure phenotypic colistin resistance in pooled E. coli populations from chicken flocks, finding higher resistance in flocks recently exposed to colistin.

A thermostable, closed, SARS-CoV-2 spike protein trimer.

This paper designs a thermostable, closed SARS-CoV-2 spike protein trimer that remains in the pre-fusion state and can be used in serological assays.

The genetic signatures of Salmonella Typhi carriage in the human gallbladder

This study sequenced S. Typhi from gallbladder carriers and acute blood isolates, finding higher genetic variability and specific mutations in gallbladder isolates that may contribute to long-term carriage and antigenic variation.

A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131

This study uses high-content imaging to screen a monoclonal antibody against E. coli ST131 isolates, identifying four binding phenotypes and linking them to genetic variations affecting O-antigen structure.

The virulence of the Cryptococcus neoformans VNIa-5 lineage is highly plastic and associated with isolate background.

The study shows that the virulence of the Cryptococcus neoformans VNIa-5 lineage varies based on isolate source and can be induced through secreted proteins in extracellular vesicles.

Assessing the virulence of Cryptococcus neoformans causing meningitis in HIV infected and uninfected patients in Vietnam

This study compares the virulence of Cryptococcus neoformans ST5 and non-ST5 isolates in HIV-infected and uninfected patients in Vietnam, finding ST5 isolates show greater variability and initial inflammatory response but lower fungal burden in mice.

Ciprofloxacin facilitates the transfer of XDR plasmids from commensal E. coli into epidemic fluoroquinolone-resistant Shigella sonnei

This study tracks the emergence of ciprofloxacin-resistant Shigella sonnei in Vietnam, showing that resistance plasmids are transferred from commensal E. coli via horizontal gene transfer, facilitated by ciprofloxacin use.

Ultrasound- and microbubble-mediated targeted delivery of therapeutic microRNA-loaded nanocarriers to deep liver and kidney tissues in pigs

This study validates a platform for ultrasound and microbubble-mediated delivery of microRNA-loaded nanocarriers to deep liver and kidney tissues in pigs, showing enhanced delivery and no tissue damage.

The Microbial Metagenome and Tissue Composition in Mice with Microbiome-Induced Reductions in Bone Strength

This study links microbiome-induced changes in vitamin K synthesis to reduced bone strength in mice through metagenomic analysis.

Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from south and southeast Asia.

This study identifies diverse antimicrobial resistant and hypervirulent Klebsiella pneumoniae strains in South and Southeast Asia, highlighting the convergence of AMR and virulence genes.

Killer whale genomes reveal a complex history of recurrent admixture and vicariance

This study uses killer whale genomes to reveal complex population history with recurrent admixture and vicariance, showing genetic homogenization at lower latitudes and differentiation at high latitudes.

Genomics of Cryptococcus neoformans

This study uses whole genome sequencing to analyze 699 Cryptococcus neoformans isolates, revealing clonal sub-clades and transmission patterns associated with HIV-related mortality.