Pharmaceutical and Antibiotic Environmental Impacts

Stage-resolved dynamics of antibiotic resistance genes and mobile genetic elements in full-scale anaerobic digestion systems

The paper analyzes antibiotic resistance genes and mobile genetic elements in anaerobic digestion systems, finding that pH and ammonia levels influence their abundance and that network analysis reveals dynamic associations across stages.

Dynamic Exchange of Bacteria and Carbapenem Resistance Genes between Sewer Biofilms and Wastewater

The paper investigates the exchange of bacteria and carbapenem resistance genes between sewer biofilms and wastewater under controlled and field conditions.

Temporal Dynamics Outweigh Fungicide Treatment in Shaping the Turfgrass Phyllosphere Resistome

This study shows that temporal changes in the phyllosphere microbiome have a greater impact on antibiotic resistance gene abundance than fungicide treatment.

Using Arabian Sea Coastal Water as a Model to Study Plasmid-mediated AMR Dissemination driven by Anthropogenic Impacts

The paper studies AMR dissemination in Arabian Sea coastal waters, identifying diverse plasmid replicons and clinically relevant antibiotic resistance genes linked to anthropogenic stressors.

A citywide metagenomic analysis reveals surface-specific microbiome and resistome patterns in outdoor urban environments across Liverpool, UK.

The paper uses shotgun metagenomic sequencing to analyze microbial communities and antimicrobial resistance genes across five urban surface types in Liverpool, finding distinct microbial and resistance profiles with higher ARG abundance on frequently contacted surfaces.

Characterization of antibiotic resistance development of E. coli in synthetic and real wastewater

This study compares antibiotic resistance development in E. coli across LB broth, synthetic wastewater, and real wastewater, finding synthetic wastewater better predicts growth and resistance than LB.

Redox oscillation frequency reshapes antibiotic resistance-gene expression through metabolic and ecological selection in a freshwater community

The paper shows that redox oscillation frequency increases antibiotic resistance gene expression in a freshwater microbial community through metabolic and ecological selection, without altering resistance gene sequences.

Integrated cross-sectoral surveillance of antimicrobial resistance genotypes and phenotypes across disparate reservoirs

This study integrates surveillance methods to profile AMR genotypes and phenotypes across diverse environmental and clinical samples, revealing high diversity and mismatches between genotype and phenotype.

Predictors Recover Most of the Metagenomic Signal for Antibiotic Resistance Gene Occurrence: A Cross-City Test of Geographic Transferability in Urban Wastewater

This study uses environmental predictors to predict antibiotic resistance gene occurrence in urban wastewater, achieving 78% of the predictive performance of metagenomic sequencing.

Biochar suppression of antibiotic resistance genes in the soil microbiome

This study evaluates how oak biochar affects antibiotic resistance gene prevalence in soil microbiomes with and without sulphamethazine, showing biochar reduces ARGs through adsorption and community shifts.

Rapid Antimicrobial Resistance Decline Coupled with Microbial Community Shifts in Sewage Polluted River Mesocosms

This study quantifies the rapid decline of antimicrobial resistance genes and microbial community shifts in sewage-polluted river mesocosms under various stress conditions.

Optimizing a Culture-Enriched Hybrid Metagenomics Pipeline to Assess the AMR Footprint of Livestock Manure in Anaerobic Digestate

This paper shows that culture-enriched metagenomics with hybrid assembly improves detection of low-abundance ARGs and reveals their genomic context and host associations in livestock manure digestate.

Global lessons from antibiotic resistance: metformin-hydrolyzing genes in transposable elements, a new threat for type II diabetic patients?

The paper investigates how metformin-degrading genes in transposable elements pose a new threat by co-selecting antibiotic resistance genes in environmental bacteria, endangering type II diabetic patients.

Influence of different pharmaceuticals on the germination and early development of two leafy vegetable species

This study examines the effects of six pharmaceuticals on seed germination and early growth of bok choy and spinach, finding species-specific responses and potential hormonal interference.

Microbial community diversity predicts invasion resistance of freshwater biofilms against antibiotic-resistant bacteria

The paper shows that microbial diversity in river biofilms predicts resistance to invasion by antibiotic-resistant bacteria, with higher diversity reducing the likelihood of establishment.

Human wastewater contamination drives the emergence of novel multidrug resistant bacteria in the Galapagos marine ecosystem.

This study maps wastewater contamination in the Galapagos and finds increased antimicrobial resistance genes and multidrug-resistant bacteria linked to human activity.

Wastewater and colloidal extracts of wastewater-irrigated soils select for resistant Acinetobacter baylyi beyond what measured antibiotic concentrations predict

The paper shows that wastewater and colloidal soil extracts select for antibiotic-resistant Acinetobacter baylyi despite low antibiotic concentrations, suggesting complex contaminant mixtures drive resistance.

Fungicide drives de novo evolution of multidrug resistance in the plant growth promoting rhizobacterium, Pseudomonas fluorescens

This study shows that fungicide exposure drives multidrug resistance in Pseudomonas fluorescens, with dual stress reducing population survival.

Evaluation of Detection Methods for Wastewater Surveillance of Antimicrobial-Resistant Bacteria from Healthcare Facilities

The paper evaluates wastewater sampling methods for detecting carbapenemase genes in long-term care facilities and finds passive sampling may be a suitable alternative to composite sampling.

From sewage to shoreline: Tracing antibiotic resistance gene trends through tropical island wastewater treatment pathways

The paper investigates how microbiome dynamics, chemical exposures, and environmental conditions influence antibiotic resistance gene (ARG) dynamics in wastewater treatment pathways in Guadeloupe.

Effects of different concentrations and combinations of antibiotics on the dynamics of intracellular transposition in Escherichia coli

This study examines how sub-inhibitory concentrations of ceftriaxone, combined with colistin and kanamycin, affect intracellular transposition in Escherichia coli, identifying thresholds for environmental impact.

Co-occurrence of Antibiotic Residues and Antimicrobial Resistance Genes in Animal Manure and Agricultural Soils from Machakos, Kiambu, and Kajiado Counties, Kenya

This study examines the co-occurrence of antibiotic residues and antimicrobial resistance genes in manure and soils from Kenyan counties, finding high levels of tetracycline and specific ARGs with strong correlations.

Bacterial metabolism of synthetic steroids across ecosystems reveals diverse biotransformation products, reactions, and enzymes

This study maps bacterial metabolism of synthetic steroids across ecosystems, identifying transformation products, reactions, and enzymes, and reveals cooperative microbial interactions in steroid metabolism.

A Two-Arm Metabolic-Efflux Adaptation Framework in Klebsiella pneumoniae under Mixed Pharmaceutical Exposure: rutA-Linked Oxidative Entry and rutR-Associated Regulation

This study investigates how Klebsiella pneumoniae adapts to mixed pharmaceutical exposure by identifying oxidative entry and efflux-mediated protection mechanisms.

Cycles of contamination and recovery: Combined sewer overflows drive acute but transient antimicrobial resistance exposure in an urban stream

This study quantifies how combined sewer overflows (CSOs) temporarily increase antimicrobial resistance in urban streams but do not establish long-term resistance due to rapid washout.

Ecological specificity and interconnectivity in Danish environmental resistomes

This study characterizes the Danish environmental resistome across 7,000 samples, identifying core and habitat-specific ARGs and their connectivity across ecosystems.

Quaternary ammonium compounds (QACs), QAC resistance genes, and QAC tolerant bacteria in livestock and human waste streams

This study compares the release of QACs, QAC resistance genes, and QAC tolerant bacteria from livestock and human waste streams, finding higher concentrations in human waste and sewage sludge.

Bio-based fertilizers shape soil microbiome, resistome and mobilome through metabolism of antibiotic-producing Streptomyces

This study shows bio-based fertilizers containing Streptomyces alter soil resistome and mobilome through ecological restructuring and carbon-dependent microbial activity.

Pulse-driven and persistent antimicrobial resistance markers in a transboundary Great Lakes connecting channel: pulse-week-stratified water-quality thresholds for One Health surveillance

The paper identifies pulse-week-stratified water-quality thresholds for detecting antibiotic resistance genes in the Detroit River, showing distinct source pathways for blaKPC and mecA.

Soil Resistomes in a Tropical Watershed are Indirectly Structured by Bacterial Community Interactions with Soil Properties

The paper investigates how soil properties indirectly shape antibiotic resistance gene (ARG) distribution in a tropical watershed by analyzing microbial community interactions.