Rhys Grinter

This study identifies how diverse Llps inhibit the BAM complex by β-signal mimicry, revealing structural and functional mechanisms across Pseudomonas species.

This study integrates surveillance methods to profile AMR genotypes and phenotypes across diverse environmental and clinical samples, revealing high diversity and mismatches between genotype and phenotype.

The paper identifies Ln-dependent PQQ-dependent enzymes in bacteria, showing they are widespread and involved in carbon metabolism.

This study identifies quinone-transporting filaments in Bacillus subtilis as an alternative to membrane invaginations for expanding respiratory capacity in Gram-positive bacteria.

This study uses AI to model RXFP1-relaxin interactions and designs potent mini-protein modulators that act as agonists or antagonists.

The paper determines the cryo-EM structure of LRRC15 and identifies the epitope recognized by the antibody samrotamab, revealing a binding mode that preserves signaling surfaces.

This study designs AI-generated anti-CRISPR proteins that inhibit CRISPR-Cas13 with high potency and specificity.

The paper shows that catabolite repression regulates hydrogen consumption in Mycobacterium smegmatis by modulating the expression of the huc operon in response to glycerol availability.

This study shows that 3-NOP reduces methane emissions in ruminants by altering microbial communities and fermentation pathways, but limits productivity gains due to shifts in hydrogen-cycling microbes.

This study shows that L-type pyocins inhibit the BAM complex at the cell surface to kill Pseudomonas aeruginosa without entering the cell.

This study designs de novo proteins to inhibit E. coli's heme extraction from hemoglobin, demonstrating their effectiveness at low nanomolar concentrations.

The paper identifies PqqU as a high-affinity PQQ importer in Gram-negative bacteria, showing its structural basis and widespread distribution across diverse environments.

This paper demonstrates that the hydrogenase Huc from Mycobacterium smegmatis can drive ATP synthesis from air, providing a traceless energy source for bacterial survival during nutrient starvation.

This study identifies how Mo-CODH and CoxG in Mycobacterium smegmatis oxidize CO and transfer electrons to the respiratory chain via quinone transport.

This paper demonstrates that a standard 120-keV TEM with a direct electron detector can achieve high-resolution cryo-EM reconstructions of various proteins.

This study shows that arabinose metabolism in enteric pathogens enhances virulence by regulating key factors, improving fitness during infection.

This study reveals how Mycobacterium smegmatis adapts to hypoxia by combining fermentative hydrogen production with carbon storage through lipid droplets.

This study identifies that Helicobacter pylori VacA is processed in endosomes by proteases into active forms that mediate intracellular effects, revealing a novel mechanism of toxin activation.