Pain Management and Treatment

Cortico-spinal Mechanisms of TENS-induced Analgesia: A Single-Blind, Three-Arm, fMRI-Based Randomized Controlled Trial

This paper compares two TENS modes, showing they reduce pain via distinct cortico-spinal mechanisms, with Conventional TENS involving spinal inhibition and Acupuncture-Like TENS relying on top-down modulation.

Combination spinal cord stimulation at different frequencies produces sustained pain relief with immune activation

This study shows that dual-frequency spinal cord stimulation produces long-lasting pain relief in rats and mice, associated with immune system activation and specific signaling pathways.

Parameter-Dependent Effects of Spinal Cord Stimulation on Neural Activation and Evoked Compound Action Potentials

This study uses computational models to investigate how anatomical and stimulation parameters affect ECAPs during spinal cord stimulation, revealing trade-offs and optimization strategies.

Selectivity of Lateral Epidural Spinal Cord Stimulation with Varying Electrode Diameters and Stimulation Configurations

This study evaluates how electrode size and stimulation configurations affect nerve selectivity in spinal cord stimulation, finding that 500 µm electrodes provide the best selectivity.

Distinct activation thresholds of unmyelinated C-fiber afferents by dorsal root ganglion and peripheral nerve stimulation

This study compares activation thresholds of C-fiber afferents using dorsal root ganglion and peripheral nerve stimulation, finding DRG stimulation activates a larger proportion of C-fibers with lower thresholds.

High-Frequency Spinal Cord Stimulation Reorganizes Cortical Cross-Frequency Coupling in a Region- and Time-Dependent Manner

This study shows high-frequency spinal cord stimulation changes cortical cross-frequency coupling in different brain regions and over time, with distinct effects in association and somatosensory cortices.

Modeling the Action-Perception Loop and its role in Phantom Limb Pain using Active Inference

This paper develops an active inference model to explain phantom limb pain by integrating sensory and action components, identifying factors like loss of limb control and residual noxious input as contributors to pain persistence.

Characterization of cutaneous reflexes elicited from saphenous nerve stimulation

This study develops and validates a method to elicit cutaneous reflexes from proximal muscles via saphenous nerve stimulation in healthy adults, showing reliable and symmetrical responses below pain thresholds.

Interindividual variations in peak alpha frequency do not predict the magnitude or extent of secondary hyperalgesia induced by high-frequency stimulation

This study investigates if variations in peak alpha frequency (PAF) predict secondary hyperalgesia from high-frequency stimulation, finding no significant association.

Exploring the Neural Correlates of Body Perception Disturbance with a Visual Hand Morph Illusion in Complex Regional Pain Syndrome: An fMRI study

This study uses fMRI to investigate neural correlates of body perception disturbances in CRPS during a visual hand morph illusion, finding increased left premotor cortex activation and altered functional connectivity in CRPS participants.

Electrophysiological Characteristics of Epidural Spinal Signals in Preclinical Models of Spinal Cord Stimulation

This study characterizes electrophysiological signals evoked by spinal cord stimulation in rats and macaques, identifying distinct waveform features and potential physiological origins of ECAPs, doublets, ESAPs, and EMG signals.

Rat Hindlimb Amputation Model Shows Analgesia and Sexually Dimorphic Cold Hypersensitivity with Immediate Targeted Muscle Reinnervation

This study uses a rat hindlimb amputation model to show that immediate targeted muscle reinnervation reduces pain behaviors and prevents neuroma formation, with sex-specific effects on cold hypersensitivity.

In vivo calcium imaging shows that dorsal root ganglion stimulation predominantly activates large-sized sensory neurons in mice

This study uses in vivo calcium imaging to show that DRG stimulation in mice primarily activates large-sized sensory neurons, with no change in response magnitude but a temporary reduction in mechanical stimulation responses.

Frequency-dependent and capacitive tissue electrical properties in spinal cord stimulation models

This study compares frequency-dependent and capacitive tissue properties in spinal cord stimulation models to assess their impact on electric fields and heating, finding that quasi-static approximation remains valid under certain conditions.

Functional Ultrasound Imaging Reveals Activation Properties of Clinical Spinal Cord Stimulation

This paper uses functional ultrasound to study spinal cord stimulation in sheep, finding that different stimulation modes produce distinct hemodynamic activation patterns in the spinal cord.

Suppression of Visceral Nociception by Selective C-Fiber Transmission Block Using Temporal Interference Sinusoidal Stimulation

This paper demonstrates that temporal interference stimulation (TIS) can selectively block C-fiber transmission in dorsal root ganglia, reducing visceral pain in mice.

Epidural Spinal Cord Recordings (ESRs): Sources of Artifact in Stimulation Evoked Compound Action Potentials

This study identifies and characterizes sources of artifact contaminating evoked compound action potentials (ECAPs) in epidural spinal cord recordings, highlighting challenges in distinguishing neural signals from artifacts in a swine model.

Paresthesia during spinal cord stimulation depends on synchrony of dorsal column axon activation

This study shows that kilohertz-frequency spinal cord stimulation activates dorsal column axons but causes asynchronous spiking, leading to paresthesia-free analgesia.

Peripheral direct current suppresses physiologically evoked nociceptive responses at the spinal cord in rodent models of pain

This study shows direct current stimulation suppresses nociceptive responses in rodent pain models, suggesting broader clinical applications for chronic pain treatment.

Novel Evoked Synaptic Activity Potentials (ESAPs) elicited by Spinal Cord Stimulation

The paper identifies and characterizes a novel electrophysiological signal, ESAPs, evoked by spinal cord stimulation that reflects synaptic activity in the spinal cord.

Spinal Cord Stimulation using time-dynamic pulses achieves faster and longer reversal of allodynia compared to tonic pulses in a rat model of neuropathic pain

This study compares time-dynamic pulses (TDPs) and tonic stimulation in a rat neuropathic pain model, finding TDPs provide longer-lasting analgesia.

Intraoperative Spinal Cord Stimulation Mitigates Pain after Spine Surgery in Mice

This study shows that intraoperative spinal cord stimulation reduces mechanical hypersensitivity in mice after spinal surgery, particularly in the treated side.

Generating Artificial Sensations with Spinal Cord Stimulation in Primates and Rodents

This study trains primates and rats to detect and discriminate spinal cord stimulation patterns, finding that sensory discrimination follows Weber's law and varies with stimulation parameters.

Pain Stickiness in Complex Regional Pain Syndrome: A role for the Nucleus Accumbens

The paper identifies brain structure and functional differences between chronic pain responders and nonresponders using MRI, showing reduced grey matter density and connectivity in the nucleus accumbens in nonresponders.

No evidence of impaired sensorimotor adaptation in Complex Regional Pain Syndrome

This study investigates sensorimotor adaptation in CRPS patients and finds no impairment in strategic recalibration or realignment, but greater endpoint errors with the affected hand.

Efferent Retargeting in Above-Knee Amputees is Positively Related to Phantom Limb Pain

This study shows that retargeting of efferent projections to residual muscles in lower limb amputees is associated with increased phantom limb pain.

Realistic Anatomically Detailed Open-Source Spinal Cord Stimulation (RADO-SCS) Model

The paper introduces an open-source SCS model with high anatomical detail and precision for simulating spinal cord stimulation.

Disputing space-based biases in unilateral complex regional pain syndrome

This study investigates spatial cognition in CRPS patients and finds no significant spatial biases, contradicting previous evidence.

Characterising sensorimotor adaptation in Complex Regional Pain Syndrome

This study investigates sensorimotor adaptation in CRPS by testing prism adaptation and finds no evidence of impaired strategic control but suggests greater realignment in the affected arm.

Sub-Optimal Learning of Tactile-Spatial Predictions in Patients with Complex Regional Pain Syndrome

This study investigates statistical learning impairments in CRPS patients using a hierarchical Bayesian model, finding reduced precision in tactile-spatial predictions compared to healthy controls.