Kip A. Ludwig

This study investigates how L-DOPA-induced dyskinesia (LID) relates to microstructural changes in brain circuits, finding brainwide alterations beyond the nigrostriatal system.

The paper identifies systematic errors in DC offset measurement at neurostimulation electrodes and proposes mitigation strategies to improve electrochemical safety assessments.

This study identifies off-target neural pathways activated during carotid baroreceptor stimulation in swine, contributing to side-effects of baroreflex activation therapy.

This study shows that sympathetic fibers are present in the rat cervical vagus nerve and that stimulating the vagus nerve can activate these fibers, leading to tachycardia rather than bradycardia.

This paper introduces an ultra-low power discrete Fourier transform for neural sensing applications, showing energy and power improvements over existing methods.

This paper characterizes the anatomy of trigeminal nerve branches and uses computational models to show that superficial branches activate nociceptors more than nerve trunks, suggesting potential off-target effects.

This study uses diffusion imaging and tractography to analyze structural connectivity changes in a rat model of Parkinson's Disease, identifying lesion-specific and compensatory neural networks.

This study shows that combining intraoperative electrical stimulation with trigeminal nerve stimulation improves motor recovery in a rat peripheral nerve injury model.

This study identifies and characterizes sources of artifact contaminating evoked compound action potentials (ECAPs) in epidural spinal cord recordings, highlighting challenges in distinguishing neural signals from artifacts in a swine model.

The paper models the Injectrode system to determine how design parameters affect neural activation, finding that larger surface area reduces pain-related activation.

This study demonstrates the feasibility of endovascular vagus nerve stimulation using electrodes in the internal jugular vein, showing that electrode positioning is critical for effective VN activation.

The paper quantifies fascicular splitting and merging in human cervical vagus nerves, finding events occur every ~560 microns and may explain clinical response variability.

This study shows that different ICMS pulse waveforms and frequencies activate distinct patterns of cortical neurons and neuropil in mice, with frequency-dependent effects on population activity.

This paper demonstrates the use of intraoperative ultrasound to visualize pig vagus nerve fascicular organization (vagotopy) and improve cuff placement for vagus nerve stimulation.

The paper introduces automatic methods for quantifying neurotransmitters using fast-scan cyclic voltammetry by improving integration boundary selection.

The paper identifies specific neuroanatomical pathways causing off-target effects of vagus nerve stimulation in pigs and characterizes dose-response curves for on- and off-target effects.

The paper characterizes the anatomy of the cervical vagus nerve in domestic pigs, identifying structural features relevant to vagus nerve stimulation and comparing them across species.

This paper demonstrates the acute and chronic performance of optically transparent μECoG grids on a thinned skull, showing stable impedances and reliable optogenetic activation and spatially distinct recordings.

This study shows that cervical vagus nerve stimulation increases cerebrospinal fluid penetration into the brain, suggesting potential clinical implications for CNS disorders.

This study investigates how frequency-dependent electrical stimulation affects calcium activity in cortical neurons, revealing spatiotemporal response patterns that depend on charge density and frequency.