Pharmacological Effects and Toxicity Studies

Investigation into the effects of sodium valproate on prepubertal mouse gonads in vivo

This study examines the effects of sodium valproate on prepubertal mouse gonads, finding no significant gonadotoxicity but a trend toward reduced germ cell density in males.

Multiomics analysis identifies VPA-induced changes in neural progenitor cells, ventricular-like regions, and cellular microenvironment in dorsal forebrain organoids

This study examines VPA-induced changes in dorsal forebrain organoids using multiomics approaches, revealing disruptions in ECM and microenvironment signaling.

Transcription factor binding and individual genetic risk for valproate teratogenicity

The paper investigates how genetic variants affecting transcription factor binding contribute to valproate-induced birth defects and identifies EP300 as a key regulator involved in this process.

Rapid effects of valproic acid on the fetal brain transcriptome: Implications for brain development and autism

This study identifies VPA-induced gene expression changes in fetal mouse brains and links them to autism and neurodevelopmental disorders.

Melatonin alleviates valproic acid-induced neural tube defects by modulating Src/PI3K/ERK signaling and oxidative stress

Rapamycin mitigates Valproic Acid-induced teratogenicity in human and animal models by suppressing AP-1-mediated senescence

This study shows that rapamycin reduces VPA-induced teratogenic effects by suppressing AP-1-mediated senescence in human and zebrafish models.

Maternal exposure to environmental levels of carbamazepine induces mild growth retardation in mouse embryos

This study shows that maternal exposure to low environmental levels of carbamazepine causes mild growth retardation in mouse embryos without affecting survival or gross malformations.

A replication study on key neurodevelopmental pathways affected by valproate treatment ofneural precursor cells

This study replicates and extends findings on valproate's effects on neural precursor cells by identifying common differentially expressed genes and enriched signaling pathways.

Aberrant induction of p19Arf-mediated cellular senescence contributes to neurodevelopmental defects

The paper investigates how aberrant p19Arf-mediated cellular senescence in neuroepithelial cells contributes to VPA-induced developmental defects in embryos.

On the Digital Psychopharmacology of Valproic Acid in Mice

This study examines the effects of valproic acid on mouse behavior and development using home-cage monitoring and pup open field assays, identifying behavioral changes linked to psychiatric and developmental outcomes.

Carbamazepine Causes Changes in Maternal Reproductive Performance and Fetal Growth Retardation in Rats

This study investigates the effects of carbamazepine on maternal reproductive outcomes and fetal development in rats, finding reduced fetal weight, implantation rates, and increased congenital malformations.