Ernst Jurgen Wolvetang

This study uses human cerebral organoids to identify PHGDH as a key metabolic factor enabling WNV infection and a potential drug target.

This study uses brain organoids to show trisomy 21 impairs oligodendrocyte maturation and neural network function in Down syndrome.

The paper uses a multi-organ microphysiological system to show that liver-derived cyclophosphamide metabolites cause neurotoxicity in connected CNS organoids.

This study identifies BLOC1S1 variants causing a hypomyelinating leukodystrophy with epileptic encephalopathy, showing impaired lysosomal and autophagic function.

This paper computationally reconstructs T. rex collagen using paleo-proteomics and protein models, enabling tunable biomaterial stiffness through inducible crosslinking.

This study shows SARS-CoV-2 infects hiPSC-derived neurons via endosomal-lysosomal pathway dependent on cathepsins, leading to HIF1alpha accumulation and phosphorylated tau, suggesting neurodegenerative effects.

The paper shows that DDHD2-generated saturated fatty acids are essential for neuronal energy production and synaptic function.

The paper shows that activating MIXL1 in hiPSCs improves endoderm differentiation and maturation.

The paper shows microbial amyloids from gut pathogens can trigger microglial hyperactivity and neuroinflammation, contributing to Alzheimer's disease progression.

This study uses patient-derived iPSCs and organoids to show mitochondrial dysfunction and oxidative stress in AT, which can be mitigated by ATM correction or antioxidants.

This study shows that Down syndrome brain organoids with choroid plexus defects enhance SARS-CoV-2 neurotropism, which can be inhibited by targeting TMPRSS2 and Furin.

This study shows senolytic drugs reduce brain aging and COVID-19-related neuropathology by targeting senescent cells in human brain organoids and mice.

This study shows that rapamycin reduces VPA-induced teratogenic effects by suppressing AP-1-mediated senescence in human and zebrafish models.

The paper examines DNA methylation patterns in neurons derived from mouse ES-cells and cultured primary neurons, finding similarities and differences in mCH deposition compared to in vivo conditions.

The paper improves the maturation of human pluripotent stem cell-derived hepatocytes using thyroid hormone and ALK5 inhibitor, enhancing markers of adult liver function.

This study identifies three distinct senescent subpopulations in human mesenchymal stem cells using single-cell RNA sequencing, revealing potential drug targets for senescence delay.

This paper describes the development of 3D human organoids that simultaneously generate choroid plexus and cortical cells, recapitulating key features of forebrain development.

This paper introduces a simple, inexpensive method to generate kidney organoids from human pluripotent stem cells, showing they develop tubular structures by day 8 and resemble fetal kidney structures by day 14.