GDF15 and Related Biomarkers

The paper develops an ISRGDF15 index to quantify the GDF15 arm of the ISR in human cells and tissues, showing its upregulation in specific tissues and correlation with age.

The paper identifies a loss-of-function variant in GFRAL associated with increased alcohol consumption in humans and shows GDF15 reduces alcohol drinking in mice.

This study identifies GDF-15 as a mechanosensing-regulated driver of melanoma pathogenesis, linking mechanical stress, vascular disorganization, and immune suppression.

This study identifies a small molecule inhibitor of GDF15 through in silico screening and validates its effects on cancer and normal cells.

This study examines salivary GDF15 levels and their associations with biopsychosocial factors and stress reactivity in healthy adults.

The paper examines cf-mtDNA and GDF15 as potential biomarkers of mitochondrial health in aging, finding GDF15 correlates with age and diabetes while cf-mtDNA does not.

The paper identifies GFRAL expression in the caudal brainstem and shows minimal expression in peripheral tissues in mice and humans.

This study examines the role of GDF15 in pregnancy and neonatal outcomes using a knockout mouse model, finding no major effects on body weight or survival.

This review evaluates GDF15's neuroprotective role and biomarker potential in neurodegeneration and neurotrauma, highlighting its upregulation and therapeutic benefits in preclinical models.

This paper shows that GDF15 levels rise with psychosocial stress, depression, anxiety, and biological aging, and that saliva GDF15 has a distinct diurnal pattern and responds rapidly to acute stress.

This study identifies GDF15 as a biomarker of the Integrated Stress Response in the CNS, showing its correlation with ISR activity in both animal models and human patients.

This study identifies fetal and maternal GDF15 as key factors in pregnancy-related nausea and vomiting, showing their roles in disease risk and severity.

The study shows that the H202D variant in GDF-15 does not affect its bioactivity but causes underreporting in R&D immunoassays, with correction equations provided.