Jack Devine

Mapping the GDF15 Arm of the Integrated Stress Response in Human Cells and Tissues

The paper develops an ISRGDF15 index to quantify the GDF15 arm of the ISR in human cells and tissues, showing its upregulation in specific tissues and correlation with age.

The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson's disease mouse model

This study shows that the gut microbiome increases mitochondrial respiration and oxidative stress in the brain of a Parkinson's disease mouse model, worsening motor symptoms.

Brain-body mitochondrial distribution patterns lack coherence and point to tissue-specific and individualized regulatory mechanisms

The paper examines mitochondrial distribution patterns across tissues and finds they lack coherence, suggesting tissue-specific and individualized regulatory mechanisms.

Mitotyping - An integrative framework to quantify mitochondrial specialization and plasticity

The paper introduces a framework to quantify mitochondrial specialization and plasticity using transcriptomic data across various contexts.

The energetic stress cytokine GDF15 is elevated in the context of chronic and acute psychosocial stress

This paper shows that GDF15 levels rise with psychosocial stress, depression, anxiety, and biological aging, and that saliva GDF15 has a distinct diurnal pattern and responds rapidly to acute stress.

Brain mitochondrial diversity and network organization predict anxiety-like behavior in mice

The paper examines mitochondrial respiratory chain capacity and its association with stress-related behaviors in mice, identifying brain networks linked to anxiety-like behavior.