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This study uses a continuum-level model to show that combining radiation with anti-VEGF and chemotherapy improves tumor suppression in growing vascular tumors.

The paper introduces an open microfluidic microtumor model combining top-down and bottom-up strategies to study tumor cell-ECM interactions and test anti-metastasis drugs.

This study evaluates generative models of protein structures using SHAPES, revealing undersampling of structural motifs and highlighting the need for better design and prediction methods.

This study eliminates the Warburg Effect in mammalian cells by knocking out lactate dehydrogenase and feedback regulators, maintaining growth rate while reducing lactate production.

This study uses CRISPR to disrupt an inhibitory receptor in NK cells and insert a GD2-targeting CAR, creating potent NK cells against GD2+ melanoma.

This study shows that increased interstitial fluid pressure and flow after spinal cord injury contribute to neural degeneration.

This study develops stimuli-responsive protein vesicles using hydrophobic ion pairing to deliver proteins and siRNA, showing effective delivery and functional activity in cancer cell lines and organoid models.

The paper develops a microdroplet emulsion system to enrich electroactive bacteria and identifies new electrogenic species from environmental samples.

The paper develops enhanced kinase translocation reporters (eKTRs) for PKA and ERK, showing improved sensitivity and dynamic range in neurons, and reveals signaling pathway crosstalk.

This study generates SOCS2 knock-out sheep using CRISPR-Cas9 ribonucleoprotein electroporation, resulting in compound heterozygotes with large deletions and trace SOCS2 expression.

This study evaluates silica and bioglass nanomaterials in a pulp-like model, finding that bioglass supports cell metabolism and homogenous distribution while silica has mixed effects.

This paper develops a high-throughput method to screen cryoprotective agents for membrane permeability and toxicity, identifying 23 compounds with favorable properties.

This study optimizes heterologous expression and fermentation conditions to produce ikarugamycin at high yields, making it more affordable for biomedical research.

This paper introduces a drop millifluidic system to screen and sort multicellular aggregates by pheno-morphological traits, enabling efficient analysis for drug testing.

EV-CLIP detects tumor-derived extracellular vesicle RNAs directly from blood plasma with high sensitivity, enabling precise monitoring of cancer mutations and EV subpopulations.

This study shows perivascular cells sense mechanical changes in collagen matrix, affecting vascular function and contributing to fibrotic conditions.

This study investigates how GBM influences microglia invasion through contractility, independent of MMP activity and glycolysis, using microfluidic systems and 3D collagen hydrogels.

This paper develops a carboxylated graphene-based biosensor for detecting IgA-SARS-CoV-2 antibodies with a limit of detection of 1:1601 v/v.

This study uses CRISPR base editing to introduce revertant mutations in F508del-CFTR, rescuing protein folding and function in CF patient-derived cells.

This paper investigates how the size of gold nanoparticle contrast agents affects CT imaging of the gastrointestinal tract in ulcerative colitis.