Brendan A.C. Harley

This paper develops a multi-material scaffold combining deferoxamine with collagen and gelatin to enhance angiogenic-osteogenic coupling for craniofacial bone repair.

This paper describes the metabolic labeling of adipose-derived stem cells to enhance their regenerative potential in mineralized collagen scaffolds through targeted delivery of bioactive molecules.

This study uses cell-laden microgels to model GBM tumor microenvironment heterogeneity and screen TMZ resistance in patient-derived xenografts.

This study shows that MSC-macrophage interactions in a mineralized collagen scaffold drive immunomodulatory and regenerative responses through IL-6 secretion and M2-like macrophage polarization.

This study uses 3D hydrogel models to investigate how extracellular matrix, hypoxia, and neuronal cells affect glioblastoma radiosensitivity, identifying potential strategies to improve treatment.

This study shows that softer, anisotropic niches promote OS-CSC properties, including chemoresistance and tumorigenicity, through transcriptional and epigenetic changes.

The paper develops a 3D in vitro model to study stromal cell migration and biomaterial integration for craniomaxillofacial defect repair.

This study shows how scaffold pore size, alignment, and glycosaminoglycan content influence macrophage polarization toward M2-like phenotypes in 3D mineralized collagen scaffolds.

This paper introduces a second lyophilization step to improve collagen scaffold handling and small molecule loading efficiency for regenerative medicine.

This paper develops a hydrogel microdroplet platform for glioblastoma drug screening, showing it can assess TMZ response kinetics and enable high-throughput testing.

This study develops a microgel-based bone marrow model to study mesenchymal stem cell (MSC) paracrine signaling's role in hematopoietic stem cell (HSC) retention and expansion.

This study modifies gelatin hydrogels through amination and thiolation to improve mechanical properties of stratified biomaterials for tissue engineering.

This study examines how the size of glioblastoma spheroids affects their invasion and response to temozolomide therapy.

This paper quantifies the rheological behavior of granular hydrogels using the Kamani-Donley-Rogers model with Brittility, showing they behave as brittle yield stress fluids with complex transient properties.

This study uses a 3D hydrogel model to investigate TMZ resistance in GBM by examining drug response and migration in heterogeneous cell populations.

This study evaluates MC-GAG scaffolds with PDLLA fixation for cranial defect regeneration, finding enhanced bone mineralization and mechanical properties compared to controls.

The paper investigates how matrix tropism affects endometriotic cell attachment patterns on ovarian tissues.

This study uses a 3D hydrogel model of the brain perivascular niche to investigate how radiation dosage and delivery rate affect niche properties in vitro.

This study investigates how hypoxia affects hematopoietic stem and progenitor cells in an engineered bone marrow model, showing improved cell maintenance under hypoxic conditions when oxygen shock is reduced.

This study investigates how GBM influences microglia invasion through contractility, independent of MMP activity and glycolysis, using microfluidic systems and 3D collagen hydrogels.

This study investigates how glioblastoma cells use hyaluronan to support proliferation and resistance, proposing a combination treatment targeting HA synthesis and degradation.

This study investigates how donor sex and passage number affect human mesenchymal stem cell osteogenic response in mineralized collagen scaffolds, finding sex-based differences in proliferation and osteogenic potential.

This paper develops a 3D hydrogel model to study how acquired temozolomide resistance affects glioblastoma cell behavior, showing changes in drug sensitivity, invasion, and cytokine production.

This study investigates how extracellular matrix properties and hormones influence chirality in endometrial endothelial cells and their vascular networks.

This paper develops a generative design method to create tunable composite biomaterials by combining Voronoi foams with collagen scaffolds for better mechanical performance and conformal fitting in bone defect repair.

This study develops a GelMA hydrogel system with co-encapsulated MSCs to enhance HSC maintenance and quiescence through dynamic matrix remodeling and signaling balance.