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This study visualizes lipid nanoparticle trafficking in non-human primates using PET imaging, showing distribution to muscle and draining lymph nodes with uptake by antigen-presenting cells.

This paper develops a 3D gingival model co-cultured with patient-derived microbiomes to study host-microbiome interactions and tissue homeostasis.

This paper presents open-source 3D printed manifolds for uniform airborne exposure of airway epithelial cells in vitro, showing reduced variation in aerosol deposition and functional responses to cannabis and tobacco smoke.

This paper introduces CRISPR MiRAGE, a miRNA-sensing guide RNA system that enables tissue-specific gene editing by modulating CRISPR activity based on miRNA signatures.

The paper develops a machine-learning model to predict protein corona composition on DNA nanostructures based on design features and protein properties.

The paper uses second harmonic generation microscopy to analyze collagen fiber organization in elephant trunk skin, revealing a bimodal distribution and entanglement that enables both flexibility and strength.

This study develops a high-fidelity CRISPR-Cas13 system that reduces C9ORF72 repeat RNA expression in a rodent model, decreasing RNA foci and reversing transcriptional deficits without affecting normal C9ORF72 levels.

NanoMelt, a ridge-stacked ensemble of regressors on four diverse sequence embeddings, predicts nanobody melting temperature from 640 curated sequences, reaching Spearman 0.832 under nested cross-validation.

This study shows that inhibiting the Hippo pathway component yes-associated protein increases nanoparticle internalization in cancer cells, independent of nanoparticle or cell properties.

The paper designs ultra-stable biopharmaceutical excipients by analyzing structure-function relationships of amphiphilic polymers, significantly improving insulin stability.

This study benchmarks deep learning uncertainty quantification methods on protein sequence-function regression tasks to improve biological sequence design.

This paper introduces a framework for optimal TMS coil placement without segmentation or meshing, validated across multiple datasets showing consistent results.

This paper develops an AR system for vitreoretinal surgery using CNNs and edge computing to align pre-op and intra-op images in real-time, achieving 14 FPS and high registration accuracy.

This study shows that weakly alkaline conditions can degrade aflatoxins by opening their lactone ring, reducing contamination without harsh chemicals.

This study shows that substrate curvature affects macrophage cytoskeletal dynamics and immunophenotype, offering a localized strategy to modulate macrophage behavior.

This study develops bioactive hydrogels containing cell-derived extracellular matrix for drug-free and cell-free bone and cartilage repair, showing induction of stem cell differentiation.

This paper develops a rapid antigen test using upconversion nanoparticles for COVID-19, achieving high sensitivity and specificity in clinical trials.

This paper develops an injectable hydrogel with antibacterial properties for tissue engineering applications, showing good biocompatibility and ability to form 3D cell aggregates.

This study shows dicarbonyl stress increases cancer cell intravasation by degrading ECM and promoting endothelial dysfunction in a microfluidic model.