Author

Tristan X. McCallister

University of Illinois Urbana-ChampaignORCID 0000-0002-1386-7311Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Alisha Y. XiongiD· 2 shared Colin K.W. LimiD· 2 shared Thomas GajiD· 2 shared Anna X.A. Wang· 1 shared Annika Carrillo· 1 shared Christopher J. FieldsiD· 1 shared Daniel G. Renshaw· 1 shared Daniela Del Bosque SilleriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBioengineering

Alisha Y. XiongORCID

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2 papers

Recent·Most cited

BioengineeringMolecular TherapyPeer-reviewedApr 24, 2026

Treatment of Huntington's disease with a pan-HTT-targeting CRISPR nuclease

Katherine Tan, Daniela Del Bosque Siller, Alisha Y. Xiong…·Thomas Gaj

This study develops a CRISPR-Cas9 system targeting all HTT alleles in HD mouse models, reducing mutant HTT and improving disease symptoms.

5 citationstop 1%

mousegenetic perturbation / CRISPR

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BioengineeringNature CommunicationsPeer-reviewedJan 8, 2025

A high-fidelity CRISPR-Cas13 system improves abnormalities associated with C9ORF72-linked ALS/FTD

Tristan X. McCallister, Colin K.W. Lim, Mayuri Singh…·Thomas Gaj

This study develops a high-fidelity CRISPR-Cas13 system that reduces C9ORF72 repeat RNA expression in a rodent model, decreasing RNA foci and reversing transcriptional deficits without affecting normal C9ORF72 levels.

19 citationstop 1%

mousegenetic perturbation / CRISPR

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