Author
University of Illinois Urbana-ChampaignORCID 0000-0001-8370-4609Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Shraddha Shirguppe, Michael Gapinske, Devyani Swami…·Pablo Pérez‐Piñera
This study uses CRISPR base editing to create HTT protein isoforms resistant to caspase-6 cleavage, reducing toxicity and neurodegeneration in a rodent HD model.
Katherine Tan, Daniela Del Bosque Siller, Alisha Y. Xiong…·Thomas Gaj
This study develops a CRISPR-Cas9 system targeting all HTT alleles in HD mouse models, reducing mutant HTT and improving disease symptoms.
Tristan X. McCallister, Colin K.W. Lim, Mayuri Singh…·Thomas Gaj
This study develops a high-fidelity CRISPR-Cas13 system that reduces C9ORF72 repeat RNA expression in a rodent model, decreasing RNA foci and reversing transcriptional deficits without affecting normal C9ORF72 levels.