Eric Andrew Appel

This paper demonstrates that localized delivery of immunotherapeutic agents via hydrogel depots enhances synergistic anti-tumor immunity in mouse tumor models.

This paper develops antimicrobial polyacrylamides using a cross-molecular machine learning pipeline trained on antimicrobial peptides, showing synergy with clinical drugs against E. coli biofilms.

This study shows that sustained delivery of a SARS-CoV-2 subunit vaccine in an adjuvanted hydrogel depot improves antibody responses in nonhuman primates compared to bolus vaccination.

This study develops a hydrogel-based vaccine delivery system that enhances immune responses and reduces reactogenicity in aged mice compared to Shingrix.

This paper develops a hydrogel depot system for long-acting peptide delivery, showing sustained release and improved therapeutic outcomes in rodents.

The paper introduces GEM multinozzle printheads to accelerate ink formulation by enabling parallelized printing and combinatorial ink mixing for complex 3D structures.

This paper develops lubricious supramolecular hydrogels to prevent peritendinous adhesions, showing improved recovery and safety in preclinical models.

This paper develops long-acting hydrogel-based depot formulations of semaglutide and tirzepatide that maintain drug levels for over 6 weeks in a rat model, showing similar efficacy to daily injections.

This study develops intranasal sertraline formulations to reduce systemic exposure while maintaining brain delivery, showing comparable brain exposure at half the dose compared to oral administration in mice.

This paper develops ACTIVATE, a hydrogel-based platform that enhances tumor control by synergizing adoptive and endogenous immunity through localized cytokine delivery and T-cell activation.

This paper develops a subcutaneous delivery platform for ultra-high-concentration protein therapeutics using a copolymer excipient, enabling reduced injection volumes and improved stability.

This paper develops a hydrogel depot system to prolong the release of broadly neutralizing antibodies, showing improved pharmacokinetics and reduced immune cell-mediated release through co-formulation with anti-inflammatory agents.

This paper improves mRNA vaccine efficacy by creating an inflammatory immune niche via injectable hydrogel depots that recruit immune cells and enhance humoral responses.

This study shows sustained delivery of multivalent influenza vaccines via polymer-nanoparticle hydrogels enhances rapid, consistent, and broad humoral immunity against homologous and heterologous strains.

This paper develops polyacrylamide-based copolymers as broad-spectrum antibiotics effective against multiple pathogens and shows they can restore the efficacy of existing antibiotics.

This paper develops a multivalent liposomal hydrogel vaccine that generates broad and durable anti-coronavirus antibody responses in mice.

This study develops a highly extensible hydrogel bioink for high-speed 3D bioprinting, showing significant improvements in print speed and resolution.

The paper designs ultra-stable biopharmaceutical excipients by analyzing structure-function relationships of amphiphilic polymers, significantly improving insulin stability.

This study investigates how dynamic hydrogel crosslink strength affects yielding behavior and cell viability during injection, finding that slower yielding transitions enhance cell protection.

This paper develops a thiol-ene click chemistry strategy to modify HPMC for tunable PNP hydrogel properties, enabling controlled drug and cell delivery.

This paper develops AAV-eluting lenses for single-step targeted expression of GCaMP in vivo, improving alignment and surgical flexibility for microendoscopic calcium imaging.

This paper discovers a broad-spectrum, non-toxic polymer virucide effective against multiple viruses at nanomolar concentrations, showing efficacy in a murine RSV model.