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REZCUE enables 3D spatial multi-omic analysis of archived FFPE tissue by preserving nucleic acids and proteins for subsequent assays.

This paper introduces a microfluidic device for detecting and sorting single fluorescent extracellular vesicles, demonstrating its utility for downstream analysis and biomarker enrichment.

This paper introduces SPEAR, a separation-free protein detection method that achieves sub-100-molecule sensitivity using engineered kinetic proofreading, outperforming existing methods for Alzheimer's and SARS-CoV-2 biomarkers.

This paper develops ultrasound-activated microdroplets for targeted chemotherapy, showing high drug encapsulation and pressure-dependent release.

This study develops a rat abdominal seroma model and shows that seroma fluid resolution does not align with stromal recovery, highlighting persistent oxidative stress, inflammation, fibrosis, and vascular remodeling.

This paper develops a framework for protein fitness prediction that improves generalization across distribution shifts by integrating structural and co-evolutionary information.

This paper introduces cell chirp ultrasound to image single cells in opaque tissues, showing it can track rare cell populations over time with high specificity and sensitivity.

This study shows pulsed field ablation (PFA) reduces tumor growth in a mouse model of pancreatic ductal adenocarcinoma by altering the tumor microenvironment and stromal cells.

This study shows that bone metabolic activity, measured by [18F]sodium fluoride uptake, correlates with mechanical strain in the tibia after acute exercise.

The paper examines how mechanical loading and pharmacological therapies affect osteocyte lacunar morphology in a mouse osteoporosis model, showing distinct adaptations in lacunar density, volume, and sphericity.

CelFDrive automates high-resolution 3D imaging of cells using deep learning for efficient detection of rare events in large populations.

This study benchmarks ten chondrogenic cell sources for cartilage regeneration using native tissue references, finding mesenchymal stem cells and fetal chondroprogenitors perform best.

This study uses flexible electrodes to track and model representational drift in mouse visual cortex, enabling a stable decoder for brain-machine interfaces.

This paper introduces an automated microfluidic platform for high-throughput cell pairing and chemical fusion, achieving higher efficiency and throughput than previous methods.

This study shows that adding lung surfactant Poractant alfa to lipid nanoparticles improves their performance for pulmonary mRNA delivery, increasing transfection efficiency and particle concentration.

This study develops a live vaccine using engineered senescent tumor cells and celecoxib to enhance immunotherapy against melanoma and pancreatic tumors.

This paper develops a 3-step image analysis pipeline to quantify VE-cadherin junction morphology in lymphatic endothelial cells, identifying new metrics that distinguish button-like and zipper-like junctions.

This study compares a low-cost saline-based tissue expansion device with conventional silicone expanders in rats, finding comparable histological outcomes and lower cost.

This study uses prime editing to identify and characterize MutSβ inhibitors that reduce (CAG)n repeat expansion.