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This study develops an integrated multi-analytical workflow to comprehensively profile biomass hydrolysate for downstream valorization.

This study uses chemical proteomics to profile cysteine reactivity in mAbs, revealing disulfide bond reduction mechanisms in CHO cell production.

This paper demonstrates that an intravenous lipid-siRNA conjugate can deliver gene silencing to brain barriers without affecting parenchymal tissue.

This study uses computational models to show how meniscus mechanics depend on microstructure and synovial fluid viscosity, finding that increased porosity significantly enhances flow velocity.

This paper improves the affinity and potency of a monoclonal antibody against Shigella flexneri 3a O-antigen using phage display and whole-cell panning, showing enhanced antibacterial activity and broader serotype recognition.

This paper develops a customized CRISPR-Cas9 base editor to correct the ACTA2 R179H mutation in a mouse model of MSMDS, improving survival and rescuing vascular and neurological phenotypes.

This study shows that platelet-derived biomaterials reduce mitochondrial dysfunction in neuronal injury models by restoring ATP production, reducing ROS, and improving mitochondrial structure and function.

The paper introduces a fibre-based structured illumination microscopy (SIM) system that simplifies setup and improves resolution without specialized optics.

This study shows that using a single plasmid for co-transfection is more efficient and results in tighter gene expression correlation than using multiple plasmids.

This study uses a mathematical model combined with OCTA images to simulate tumor-induced angiogenesis in retinal hemangioblastoma, revealing critical insights into the timing and dynamics of vascular development.

This study reveals analog epigenetic memory through graded DNA methylation, showing its temporal stability and role in gene expression regulation.

This paper develops a 4D bioprinting method using cell-contractile forces to drive shape changes in cell-laden constructs, demonstrating simultaneous morphing and chondrogenic differentiation.

This study evaluates how different types of noise affect motor unit decomposition using HD-sEMG, finding that global noise severely impacts results while localized noise has minimal effects.

This study develops PSA-functionalized MAP scaffolds that modulate immune responses and reduce inflammation after ischemic stroke.

This study evaluates how signal degradation affects motor-unit-based gesture recognition using HMI, finding that LDA and DNN perform differently under noise and spatial perturbations.

This paper designs phosphorylation-induced protein switches that control transcription in cells, demonstrating their functionality in synthetic signaling.

This study develops and optimizes a cutaneous suction-mediated DNA transfection method in mice, demonstrating effective delivery of DNA vaccines and proteins with strong immune responses.

This paper introduces a modular, reusable, and perfusion-ready microphysiological system to simplify organ-on-chip technology for broader use.

This paper demonstrates the self-assembly of a disordered peptide into stable shells and scaffolds through phase transitions at interfaces, with potential applications in biomedical engineering.

This study develops SABER hydrogels that extend drug release and therapeutic effect for small molecules and biologics in preclinical models.