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The paper develops a time-dependent model for cortical bone adaptation to mechanical loading using linear control theory and differential equations to analyze different response types.

Embedding day-8 cerebral organoids in Geltrex loaded with human brain microvascular endothelial cells, plus VEGF-supplemented mixed media, yields integrated endothelial networks and almost three-fold less apoptosis.

This paper introduces a bacteria-powered living material that significantly enhances coral larval settlement on restoration substrates.

This paper engineers Escherichia coli Nissle to deliver therapeutic peptides using CRISPR-Cas12 and an AI-based pipeline for peptide prediction.

This study uses dynamic optical coherence tomography to assess ex vivo mouse kidney viability during cold storage, identifying metrics that correlate with tissue health and deterioration.

The paper develops a genetic tool for Bactrocera zonata by creating a chromosome-level genome and CRISPR/Cas9-induced white-eye mutants to aid in Genetic Sexing Strain development.

This paper engineers human TRPV1 channels to detect near-infrared light by shifting their temperature sensitivity, enabling light-induced heat activation in retinal cells without immunogenicity issues.

This study estimates speech reception threshold using ear-EEG and finds it is reliable when combining in-ear and around-the-ear electrodes.

This paper designs and characterizes agonists that tune G-CSFR activity to bias granulopoiesis over proliferation, showing improved stability and selectivity compared to native G-CSF.

This study presents a computational framework for designing auxetic fiber scaffolds using Melt Electro-writing, validated through FEM modeling and experimental testing to achieve tailored mechanical properties for soft tissue engineering.

This paper develops a strategy to reduce immunotoxicity in self-amplifying RNA by encoding immune suppressors that bypass translation shutdown, enabling sustained transgene expression in mouse cells.

The paper demonstrates lipid nanoparticle-mediated mRNA delivery enables rapid, organ-wide protein expression in human-sized porcine donor kidneys during normothermic machine perfusion.

This paper introduces a hybrid scaffold for bone-on-chip systems that mimics bone stiffness and enables single-cell studies, showing enhanced osteogenic marker expression through bioactivity and geometry.

Smartphone-video biomechanics (OpenCap) reproduced four timed function tests (r > 0.98) and separated facioscapulohumeral from myotonic dystrophy better than test times (balanced accuracy 82% vs 50%; 129 participants).

This paper introduces a one-pot cloning and protein expression platform that integrates mutagenesis, plasmid assembly, and functional testing in a single reaction, validated with multiple protein systems.

This study investigates how DNA origami nanoparticle shape and ligand patterning affect diffusion in intestinal mucus, finding that topology-specific optimization is crucial for mucus penetration.

This study develops 3D human skeletal muscle constructs from hiPSCs that can undergo electrically controlled remodelling, showing distinct morphological and force-generating responses to different mechanical boundary conditions.

This paper introduces a convex gamma GLM for heartbeat dynamics, improving parameter estimation and enabling prediction and information quantification in cardiac data.

This study investigates how fibroblast concentration, conditioned media, angiogenic factors, and luminal flow affect microvascular network morphology in a microfluidic vasculature-on-a-chip, introducing void-based metrics for more sensitive analysis.

This paper introduces 4Pi-SRS, a label-free super-resolution imaging technique that improves axial resolution by combining SRS with 4Pi-interferometry, enabling high-resolution imaging of lipid structures in cells.