Discover, rate, and discuss biology papers.

This paper develops a TGFβ trap that crosses the blood-brain barrier to modulate the immunosuppressive tumor microenvironment and enhance immunotherapy efficacy in glioma models.

This paper evaluates two approaches for improving brain tumor segmentation: a novel 2D U-Net architecture and a multi-channel input representation using cross-modal subtraction maps, showing both contribute to performance improvements.

This study shows that a stent designed to better accommodate limb-flexion deformation reduces inflammation and neointimal hyperplasia compared to a standard stent.

The paper develops an optimized model of endothelial signaling using ODEs, showing that most responses can be captured with shared parameters, with only a few reactions needing specific parameterization.

This study compares extracellular vesicles from bioreactor and batch cultures of brain endothelial cells, finding similar functional properties and protein content, with bioreactor cultures producing higher yields.

The paper engineers EV-mimetic vesicles to study protein loading and uptake, finding that protein properties influence incorporation and biodistribution.

This paper develops a flow-triggered electrochemical aptasensor for continuous 17β-estradiol monitoring without chemical regeneration, achieving low detection limits and stable performance in real human sweat.

This paper develops interconnected macroporous GelMA scaffolds using temperature-controlled spinodal decomposition to optimize pore size for enhanced cell culture.

This study develops mtBE-VLPs for transient mitochondrial base editing, achieving high efficiency and reduced off-target effects in vitro and in vivo.

golgi automates nerve model generation and recruitment simulation from images, offering a scalable open-source platform with Python API and GPU acceleration.

This paper introduces T-REX, an agentic framework for protein binder design that adaptively allocates compute resources across methods, achieving higher throughput of structurally distinct hits than baselines.

FD-SCoPE answers clinician questions about clinical trial evidence tables using language models, providing verifiable answers and learning from expert feedback.

This study investigates how pancreatic progenitor cells respond to fluid shear stress, finding transcriptomic changes and reduced YAP1 activity.

This paper compares hydrothermal and microwave-assisted synthesis of carbon quantum dots from bearberry extract, showing how synthesis method affects surface chemistry, photophysical properties, and biological activity.

This paper introduces a designed nanofiber immunogen platform that primes antibodies with increased conformational tolerance toward HIV-1 fusion peptide, showing efficacy in mice and infant non-human primates.

This paper develops a 4D GelMA-Cad/gelatin hydrogel for vascularized soft tissue bioprinting, showing improved print fidelity and matrix mechanics for tissue modeling.

This paper demonstrates the use of commercial flow cytometry to sort HEK293T cells with controlled numbers of microlaser particles, enabling defined cellular labeling and spheroid formation.

This study improves TEV protease activity through loop engineering using a phagemid-based selection system combined with deep learning.

This study uses AtaA to create enzymatically active surfaces through oxidative tyrosine coupling, showing trade-offs between cross-linking and adhesion.

This study develops mechanochemically reprogrammed stem cell exosomes that enhance immunomodulatory function and macrophage uptake for pulmonary fibrosis therapy.