Discover, rate, and discuss biology preprints.

This study examines snake venom fluidic properties and develops non-toxic mimics to model venom flow for biomedical and evolutionary research.

This study shows TGF-β1 causes sex-specific cardiac myofibroblast activation and secreted factor differences on hydrogels, influencing fibrosis.

This study shows that deep UV treatment increases the surface stiffness of soft silicones without affecting their bulk properties, as measured by nanoindentation and spectroscopy.

This paper introduces a 3D microdissection method combining CNC milling and light-sheet microscopy to study tumor evolution in complex 3D structures.

The paper identifies stress granule coarsening as a critical factor in cardiac electrophysiological dysfunction under oxidative stress.

This study evaluates consumer acceptance of different burger formulations by combining sensory evaluation and texture analysis, finding that moistness and meatiness are key factors influencing preference.

The paper screens 1,243 intracellular domains to identify ELMs and their combinations that influence CAR T-cell immunophenotype differentiation.

This study uses a biomechanical model to show that collagen anisotropy is essential for accurately simulating fingertip strain patterns during normal loading.

The paper investigates how autophagy induction reduces host cell proteins in CHO cell cultures, improving polysorbate stability and mAb productivity.

This study develops an in vitro intracranial aneurysm model with cardiovascular flow to investigate endothelial remodelling and identifies cytokine signatures as potential biomarkers for IA remodelling.

This paper develops a multi-modal flow phantom for PET and spectral CT to improve blood flow quantification by enabling tunable perfusion imaging.

This paper introduces a hydrogel-based biosensor that accelerates bacterial interaction with reporter molecules through engineered transport, achieving faster and more accurate detection of infections and antimicrobial susceptibility.

This paper introduces collagen-alginate hybrid hydrogel microtubes (ColAlgTubes) that enhance cell culture efficiency by improving adhesion, mechanical stability, and scalability.

This paper develops a microfluidic platform to profile drug responses in NSCLC patient-derived organoids, showing that microenvironmental cues affect therapeutic responses and resistance mechanisms.

This paper develops a biodegradable nanoparticle-in-implant platform for sustained and light-boosted pirfenidone delivery to treat vocal fold fibrosis.

This paper introduces APQ, a pore-resolved platform for quantifying amyloid aggregation and amplification, revealing population-level structural insights beyond conventional ThT assays.

The paper introduces a microfluidic system for long-term high-resolution imaging of organotypic brain slices to study neural responses to glutamate.

This paper introduces MIRACLES, a method to image cell membrane potential dynamics using vibrational optoacoustic detection, and demonstrates its application in monitoring glucose-stimulated insulin secretion in beta-cells.

This study quantifies parasitic losses in UHF MRI receive coils and shows how they reduce predicted SNR, providing guidance for improving coil design.

This paper develops ovoprotein microgels for bioprinting that are structurally adaptive and biologically instructive, enabling vascularized and mineralized tissue constructs.