Discover, rate, and discuss biology preprints.

This paper develops a 3D biomimetic scaffold model to support in vitro lactation by human milk-derived mammary epithelial cells, enabling secretion of beta-casein and milk-fat-globules.

This study uses an AI platform to identify sex-specific drug combinations targeting aortic valve myofibroblast activation, revealing sex-dependent efficacy and interactions.

This paper introduces TRACE, a method for instant collagen gelation and patterning, enabling applications in biofabrication and tissue engineering.

HD2Net improves fluorescence microscopy image quality by simultaneously denoising and correcting aberrations without additional hardware, outperforming existing methods in resolution and contrast.

This study presents an enzyme-free DNA templating system that produces sequence-specific dimers with weak product inhibition, demonstrating a design principle for information propagation through molecular templating.

This study evaluates differences in margin of stability (MoS) calculations using various base of support definitions and investigates the impact of anthropometric factors on MoS measures.

This paper introduces BADASS, an optimization algorithm for protein design that improves fitness prediction and sequence diversity compared to existing methods.

This paper applies machine learning models to CTG data to classify fetal health, finding gradient boosting provides the highest accuracy.

This study demonstrates real-time monitoring of oxygen utilization during photodynamic therapy using ultrasound-guided photoacoustic imaging in murine tumor models.

This study models tumor growth and macrophage dynamics in a multiphase system, showing how macrophage heterogeneity affects tumor progression and proposing an immunotherapeutic strategy.

This study benchmarks AI models for antibody CDR sequence design, finding that specialized models like AntiFold perform better in complex regions while general models struggle with antibody-specific nuances.

The paper uses long-read sequencing to analyze unintended on-target mutations in mouse zygotes edited with AAV-delivered CRISPR RNP complexes.

This study shows that high-fat diet worsens age-related loss of bone fracture toughness in C57BL/6JN mice.

This paper develops eTd-mtABEs, engineered mitochondrial A-to-G base editors with enhanced efficiency and targeting scope, enabling efficient generation of mtDNA disease models in rat embryos.

This study engineers a controlled cardiac multilineage co-differentiation process using statistical design of experiments to generate cardiomyocytes, mural cells, and endothelial cells from iPSCs with high controllability and maturity.

This paper introduces PaLS-iDCS, an enhanced DCS method that improves SNR and sensitivity to deep tissue hemodynamics without requiring time-resolved detection.

This study investigates the function of the scaly-tail organ in Anomalurus pelii, finding it enhances friction and stability during arboreal locomotion on intermediate roughness substrates.

This study examines how metachronal rowing performance scales with Reynolds number across four orders of magnitude, finding consistent Strouhal numbers and linear scaling of swimming speed with Re.

This paper develops micro-invasive probes for dual chemical and electrical neural activity recording in nonhuman primates, demonstrating long-term functionality over one year.

This paper develops a vaccine formulation to reduce inflammation after traumatic brain injury by inducing immunosuppressive cells and improving motor function in mice.