Michael Mak

This study shows that C9, a component of membrane attack complexes, forms non-cytolytic intracellular aggregates that promote inflammation and EC activation through aggrephagy and NF-κB activation.

The paper introduces a photocrosslinkable inhibitor, AZ, to selectively and spatiotemporally control Arp2/3 complex-dependent actin nucleation in live cells.

The paper shows that sustained cell volume expansion in melanoma primes cells to develop drug tolerance while increasing susceptibility to CD8+ T cell killing.

This study shows that cilia loss in male germ cells causes centriole clustering and elimination, leading to infertility, while zygotene cilia are not essential for meiotic processes.

This paper develops a 3D bioprinting method to create collagen filaments with tunable mechanical properties, achieving strength surpassing native tendon.

This study shows that epidermal stem cells regulate periderm injury repair by forming specialized intercellular junctions through interactions with the extracellular matrix.

This paper introduces TRACE, a method for instant collagen gelation and patterning, enabling applications in biofabrication and tissue engineering.

This study shows bone-derived nanoparticles reduce IR-induced damage in BMSCs by restoring molecular pathways and enhancing regenerative function.

This study shows that volumetric compression in liver cancer cells leads to transcriptional reprogramming, increased invasiveness, and chemoresistance, with potential reversal via calcium signaling.

The paper investigates how volumetric compression affects Rho GTPase balance and mechanobiological cell state transitions through physical and molecular changes.