Thomas E. Ouldridge

This paper introduces an enzyme-free DNA-based templated dimerization reaction controlled by a fuel strand that displaces product to overcome inhibition, enabling information propagation from templates.

This paper introduces an enzyme-free DNA strand displacement network that uses DNA templates to assemble non-covalent DNA multimers under isothermal conditions, achieving far-from-equilibrium product formation.

The paper introduces a photolithographic method to pattern sealed microfluidic devices with biomolecules, demonstrating versatility in surface modification and comparing covalent and noncovalent DNA binding.

This study presents an enzyme-free DNA templating system that produces sequence-specific dimers with weak product inhibition, demonstrating a design principle for information propagation through molecular templating.

This study introduces a DNA strand displacement-based kinetic proofreading motif that enhances molecular recognition specificity in templated dimerization reactions by consuming DNA-based fuel.

The paper characterizes RNA/DNA hybrid strand displacement kinetics, finding strong sequence dependence and large rate differences between RNA-DNA hybrids and DNA-DNA duplexes.

The paper develops a modular toolset to improve the performance and standardization of electrogenetic systems for spatiotemporal gene expression control.

This paper demonstrates an RNA-based toggle switch using inhibitory RNA aptamers that can toggle between two states by sequestering RNA aptamers with DNA sequences.

This paper describes a method to generate RNA complexes in situ using self-cleaving ribozymes for synthetic molecular circuits.

The paper introduces a method to enhance thermodynamic drive in DNA strand displacement reactions by strategically placing mismatches, without significantly affecting forward reaction rates.