Discover, rate, and discuss biology preprints.

This paper develops an enzymatically active granular matrix for on-chip bone-like mineralization, demonstrating rapid in situ mineral formation under controlled conditions.

This paper develops a modular biofabrication strategy to create a vascularized skeletal muscle model by separately maturing muscle and vascular compartments and then assembling them.

This study develops a workflow to generate morphological signatures of bacterial progeny under antibiotic stress, revealing distinct morphologies linked to survival and antibiotic type.

This study uses a magnetoactive hydrogel to investigate how curvature affects endothelial cell mechanosensing, finding that curvature influences YAP localization and junctional dynamics independently of shear stress.

This study compares wearable and lab motion capture systems in detecting sleep deprivation through running biomechanics using machine learning, finding both systems can identify individual biomechanical changes but fail between-subject classification without personalized data.

This paper uses Ensemble Kalman Filters to estimate intracellular nucleotide sugar donors in CHO cell cultures from extracellular measurements, improving metabolic state inference.

This paper introduces a staged approach to Fab discovery by sequentially enriching heavy-chain variants and remating them with light-chain repertoires to overcome combinatorial complexity in antibody library screening.

This paper develops a computational model to simulate mechanical stretching of cultured cells on a flexible membrane and connects it to chromatin deformation.

This paper develops a method to print collagen-I scaffolds directly inside organ-on-chip devices, enabling perfusable and stretchable mammary tissue models with compartmentalized fluidic control.

The paper examines cathepsin expression and activity in vaginal fluid across bacterial vaginosis diagnoses and community state types, finding differences in expression but not activity.

This study investigates the effects of different molecular weight components of an intravascularly infusible decellularized extracellular matrix (iECM) on vascular binding and pro-reparative gene expression after myocardial infarction.

This paper develops a 3D-printable, cytocompatible hydrogel from Acinetobacter baylyi ADP1 extracellular matrix, demonstrating its versatility for biofabrication.

This paper shows that adjusting Activin A levels in a 3D bioreactor system can generate liver-like structures from human stem cells, mimicking early liver development.

This paper develops a dCas9-based tool to measure DNA sequence proximity and orientation, finding that rotational alignment significantly affects dCas9 interactions.

This study examines how attentional load affects intracortical brain-computer interface (iBCI) performance during dual-tasking, finding robust performance but individual variability.

This study decomposes gait cycles using a dynamic system framework to identify coordination patterns in human locomotion.

This study investigates how lactate:propionate ratios and substrate concentrations affect valerate production in continuous lactate fermentations.

This study benchmarks machine learning models for enzyme engineering using a curated dataset, finding zero-shot predictors are most generalizable but still modestly correlated with activity, with consensus models improving precision.

The paper introduces COMPASS, a method for sequence-independent imaging of glycoRNAs in living cells and tissues, revealing their distribution in cancer and neurogenesis.

This paper develops a sprayable antimicrobial film that prevents wound and medical device infections by forming a nanometric polyelectrolyte complex on surfaces.