Yue Chen

Sequence-Independent In Situ Imaging of GlycoRNA in Living Cells and Tissues based on COMPASS

The paper introduces COMPASS, a method for sequence-independent imaging of glycoRNAs in living cells and tissues, revealing their distribution in cancer and neurogenesis.

Computational design of constitutively active mutants of Dopamine D2 receptor inspired by ligand-independent activation mechanisms

The paper identifies a constitutively active mutant of the dopamine D2 receptor using computational methods and experimental validation.

4D Single-Cell Spatial Transcriptomics Reveals Dynamic Morphogenetic Gradients and Regenerative Domains in Planarians

This study constructs a 4D spatiotemporal transcriptomic map of planarian regeneration using Stereo-seq, identifying dynamic gradients and an injury-induced regenerative zone.

RF-SIRF defining reversed DNA replication forks with single-cell and spatio-temporal resolution reveals a replication stress specific epigenetic code

The paper introduces RF-SIRF, a method to measure reversed DNA replication forks with single-cell and spatio-temporal resolution, revealing their accumulation at the nuclear periphery and an epigenetic code for replication stress.

Revealing molecular determinants of ligand efficacy and affinity at the D2 dopamine receptor through molecular dynamics simulations

This study uses molecular dynamics simulations to uncover the molecular mechanisms of ligand activation in the D2 dopamine receptor and identifies differences in activation mechanisms between dopamine and adrenergic receptors.

Mid1 deletion leads to cognitive dysfunction in Opitz syndrome by regulates neural rhythms through the inhibition of p-Creb by PP2Ac

Spatiotemporally selective ATP events from astrocytes encode injury information and guide sustained microglial response

The paper identifies Inflares, spatiotemporally selective ATP events from astrocytes, which encode injury information and guide microglial response, showing their role in both injury amplification and therapeutic reversal.

An ultrasensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo

The paper develops an ultrasensitive GRABATP1.0 sensor to detect extracellular ATP in real time, demonstrating its use in vitro and in vivo across multiple conditions.

Notorious Novel Avian Influenza Viruses H10N8 and H7N9 in China in 2013 Co-originated from H9N2

This study shows H7N9 and H10N8 avian influenza viruses co-originated from H9N2, sharing mutations that affect pathogenicity and spread.