Discover, rate, and discuss biology preprints.

The paper re-examines mRNA-protein correlations in E. coli, develops a theoretical framework accounting for cell growth and division, and validates it with simulations and data.

This paper introduces holoV3C, a method for precise 3D tracking of non-planar eukaryotic flagella using DHM, achieving high temporal and axial resolution for flagellar dynamics analysis.

This paper reduces a complex radiobiological model to a simpler three-parameter model using MBAM, showing it aligns with known theories and predicts new synergistic effects between radiation types.

The paper identifies bistability in the cyanobacterial circadian clock as a mechanism for temperature compensation, linking it to amplitude regulation and phosphorylation dynamics.

This study investigates the interaction of myristoylated GRASP65 and GRASP55 with lipid membranes using reconstitution and various analytical techniques, revealing their impact on membrane dynamics.

This paper introduces a variational method to estimate diffusion coefficients and free-energy profiles from molecular dynamics trajectories under equilibrium and nonequilibrium conditions.

This study shows that macromolecular crowding promotes DNA writhe under tension by inducing a contractile force dependent on crowder concentration and molecular weight.

The paper introduces REVEAL, a mass spectrometry method to identify receptor-specific lipid binding in mammalian membrane proteins, showing agonism alters lipid occupancy and plasmalogen lipids are depleted under oxidative stress.

This study shows that growth-repulsion feedback in branched cells leads to hyperuniform tissue patterning and efficient tiling during development.

This study reveals that PDZ1 in the Syntenin-1 tandem domain exhibits intrinsic conformational diversity, contrasting with PDZ2's structural conservation, and suggests functional specialization for ligand recognition and domain stabilization.

This study investigates how Npl4 decodes polyubiquitin chain length and regulates D1-D2 coupling in human VCP/p97 using smUbiRAD, revealing chain-length thresholds and disease-linked mutations.

The paper develops a theory to explain condensin's forward and backward steps during loop extrusion, revealing catch bond-like behavior under mechanical force.

This study designs synthetic biomolecular condensates that control microtubule assembly through tunable material properties and interfacial rheology.

The paper quantifies the conformational dynamics of the ribosomal tunnel constriction in E. coli, showing its flexibility and response to nascent polypeptides.

The paper analyzes the genetic diversity and structural properties of SdrD in S. aureus PJI isolates, identifying three subtypes and showing structural rigidity despite calcium depletion.

This study shows synthetic transcriptional condensates exhibit dynamic behaviors driven by RNA synthesis and degradation, revealing how reaction kinetics influence condensate formation and function.

This study uses molecular dynamics simulations to show how respiratory aerosols create structured microenvironments that influence SARS-CoV-2 stability and spike dynamics.

This study directly observes ATP-driven ubiquitin chain handling by Cdc48, revealing non-processive and processive modes of action and their role in ubiquitin unfolding and chain selection.

This study investigates how ionic conditions and structural flexibility affect RNA folding by comparing cryo-EM and XRD structures of the SARS-CoV-2 frameshifting stimulatory element.

This study shows how a designed generalist binding protein can evolve into specific functions like a fluorophore binder and an efficient enzyme through weak, promiscuous interactions.