Heterozygote advantage cannot explain MHC diversity, but MHC diversity can explain heterozygote advantage
The paper argues that heterozygote advantage cannot explain MHC diversity and that MHC diversity may instead explain heterozygote advantage.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
The paper argues that heterozygote advantage cannot explain MHC diversity and that MHC diversity may instead explain heterozygote advantage.
Xin Li, Ruixue Chen, Yangyi Zhang…·Guojie Zhang
The paper identifies conserved regulatory programs in placental invasion across mammals and links their dysregulation to pregnancy disorders and cancers.
Enes Dilber, Jiatong Liang, Junyan Tan, Jonathan Terhorst
The paper introduces a new method for inferring complex demographic models from genetic variation data, achieving significant speedups over existing methods.
Eleonore Susi, Zhenzhen He, Filip Thörn…·Maria Cortázar-Chinarro
This study compares immunogenetic and microbiome diversity in two toad species across latitudes, finding species-level differences in MHC diversity and microbiome composition that may affect disease susceptibility.
Tomos Potter, Hanna Kokko, David N. Reznick…·Ronald D. Bassar
Heritable variation is maintained due to resource competition being more intense among kin.
Emma Rangel‐Huerta, Meiru Wang, Stephanie H. Nowotarski…·Matthew C. Gibson
This study uses X-ray tomography to compare internal polyp architecture across four coral species, revealing species-specific patterns of tissue organization and connectivity.
Qifan Wang, Michael D. Edge, Joshua G. Schraiber, Matthew W. Pennell
This paper introduces a method to reduce false positives in phylogenetic regression by incorporating eigenvectors of the phylogenetic variance-covariance matrix and presents a new R package for visualization.
Joanna Różańska‐Wróbel, Karolina J. Przesmycka, Józefina Wasilewska…·Jacek Radwan
The paper investigates whether Borrelia afzelii OspE coevolves with bank vole CFH, finding positive selection on OspE but no direct genetic association.
Surajit Pal, Anton Mohn, Michael Habig…·Hinrich Schulenburg Y
This study investigates how resistance to different antibiotics affects virulence in Pseudomonas aeruginosa, finding antibiotic-specific trade-offs between resistance and virulence.
Thomas Marcussen, Andrea S. Meseguer
The paper challenges the claim that polyploidy in plants is linked to environmental upheaval by identifying methodological flaws in a previous study.
Joséphine Ledamoisel, Vincent Debat, Violaine Llaurens
This study examines how sympatry influences the evolution of iridescence in Morpho butterflies, finding evidence of convergence due to evasive mimicry and sexual dimorphism in selective pressures.
Kirstyn Brunker, Alejandra Dávila-Barclay, Elvis W. Díaz…·Ricardo Castillo-Neyra
Huangyi He, Qianwei Su, Lu Cao…·Qi Zhou
The paper identifies new genes involved in the evolution of parasperm classes in Drosophila, showing their role in sperm divergence and altruistic traits.
Anneli Brändén, Stephen P. De Lisle
The paper investigates stabilizing selection on Drosophila wing shape and shows it constrains macroevolutionary change despite genetic variance.
Marie Merle, Gabin Rignault, Florence Mougel…·Myriam Harry
This study analyzes the evolutionary dynamics of chemosensory genes in Rhodnius species, finding that odorant receptors (ORs) show significant expansion and selection, while other families remain conserved.
Nayma Romo Bechara, Nikhil S. Bardeskar, Heather A. Hopkins…·Kasie Raymann
This study shows that exposure to a ciliate predator reshapes evolutionary dynamics in Pseudomonas aeruginosa by maintaining genetic diversity and altering mutation frequency distributions, without consistently increasing virulence.
Timo J. B. van Eldijk, Jana M. Riederer, G. Sander van Doorn, Franz J. Weissing
This paper uses simulations to show that condition-dependent mutation rates evolve in changing environments, enhancing evolvability and adaptation.
Victoria S. Farrar, Salvi Patel, Alexandra X. Sumarli…·Alison M. Bell
The paper compares reproductive strategies in stickleback ecotypes, showing how hormonal tradeoffs shape life history divergence through gene expression and androgen production differences.
Carlo Longhi, Luis A. Martínez-Vaquero, Fernando Wario Vázquez, Vito Trianni
This paper shows that emergent leadership in heterogeneous populations promotes cooperation through evolutionary game theory, especially when few individuals act as leaders.
Mehrnaz Afkhami, M Li, Crystal Liang…·Andrew G. Clark
The paper applies the Bradley-Terry model to quantify sperm competition outcomes in Drosophila melanogaster by analyzing pairwise mating trials and estimating genotype-specific competitive success.