Discover, rate, and discuss biology preprints.

This study finds that inbreeding depression is higher in benign than stressful environments, with a unimodal relationship between stress intensity and inbreeding costs.

The paper shows that protein fitness landscapes appear simpler when analyzed using an evolution-aware framework that accounts for the non-uniform distribution of sequences in nature.

The paper shows that beneficial intergenerational fitness effects in C. elegans can lead to detrimental transgenerational effects, demonstrating evolutionary trade-offs across generations.

This study identifies auditory genes in moths through evolutionary analysis and finds evidence of selection in hearing-related genes.

The paper analyzes sedimentary ancient DNA from Ireland to reveal Late Pleistocene faunal connectivity with Eurasia, identifying new mitochondrial lineages in cave hyenas and woolly mammoths.

This paper presents a chromosome-level genome assembly of Calotes wangi, identifying expanded gene families related to steroid metabolism and epigenetic processes.

The paper models how plasmid and chromosomal compensation affect the spread of antimicrobial resistance, finding short-term plasmid-borne compensation dominates but long-term chromosomal or combined compensation leads to multidrug resistance.

This study develops an agent-based model to simulate how social network dynamics and demographic changes influence cardiovascular disease incidence over time.

This study resolves phylogenetic conflicts in Collembola by showing ancient rapid radiation and incomplete lineage sorting, supporting Poduromorpha as the earliest-diverging lineage.

This paper extends the SNaQ method to infer complex semi-directed phylogenetic networks, showing improved accuracy and scalability for reconstructing reticulate evolutionary histories.

This study identifies de novo genes in crickets that originate from repetitive DNA, showing that such sequences are more common in older genes than in recent insertions.

This study identifies reproductive timing as a key trait covarying with defense against parasites in C. elegans, rather than resistance.

This study evaluates how protein language models capture mutational processes and fitness landscapes, finding that explicit mutational accessibility improves predictions while historical biases degrade performance.

This study analyzes flight diversity in Diptera by integrating morphology, kinematics, and aerodynamics, revealing how scaling, aerodynamic constraints, and evolutionary trade-offs shape flight adaptations.

This study introduces a stochastic framework for phylogenetic shape analysis using diffusion processes and applies it to butterfly wing data.

The paper quantifies reverse-complement symmetry in codon usage across taxa and shows it is not fully explained by compositional constraints.

This study identifies common molecular determinants that enable potyvirus adaptation to new hosts and resistance breakdown across multiple Asteraceae species.

This study examines the effects of temperature and AalDV2 infection on Ae. albopictus survival and development, finding no significant survival impact from the virus but temperature-dependent developmental changes.

The paper quantifies introgression in 4126 ant colonies, finding 23% of species show introgression, more than double previous estimates, and suggests postzygotic barriers constrain it.

This study compares human and chimpanzee neurons to show that human neurons have altered lipid metabolism and trafficking, contributing to delayed synaptic maturation during brain development.