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The paper analyzes polymorphic transposable elements in human pangenomes to reveal regulatory evolution mechanisms before fixation.

The paper identifies resilience factors in aged mice using a genome-scale ORF screen, finding NKX2-5 variants that restore vision and reduce frailty.

Mendel is a foundation model trained on human whole genome sequences to prioritize regulatory variants and improve gene expression prediction.

The paper develops a stochastic model of transposable element dynamics showing overdispersion arises naturally from transposition-deletion-selection balance and validates it with Drosophila data.

This study uses single-cell RNA sequencing to analyze how fibronectin fragment treatment alters chondrocyte states and transcriptional programs in primary human cells.

This study identifies cell type-specific eQTLs in the human pancreas using single-cell RNA-seq data and deconvoluted bulk RNA-seq data, revealing new genetic signals and associations with metabolic disease.

The paper uses single-cell RNA-seq and machine learning to classify CASR variants as gain- or loss-of-function, achieving high accuracy and clinical validation.

This study identifies Snurportin-1 as critical for skeletal muscle homeostasis by linking RNA processing to extracellular niche integrity and myogenic progenitor maintenance using a zebrafish model.

This paper introduces a matrix multiplication framework for genotype-by-environment interaction in genomic prediction, showing improved accuracy over traditional methods.

The paper investigates transcriptional adaptation in paralog gene families using Perturb-seq, finding six paralog pairs show adaptation and identifying mechanisms like nonsense-mediated decay and nuclear import.

The paper shows that the correlation measure r2 for linkage disequilibrium can be understood through probability methods, demonstrating equivalence between correlation and probability approaches in Wright-Fisher models.

The paper shows that the strength of a gene's first 5' splice site determines its expression level through intron-mediated enhancement, independent of 3' splice site strength.

This study examines body size, dental pathology, and maternal genetic diversity of ancient horses in the eastern Baltic Sea region and western Russia to better understand horse domestication timelines and patterns.

This paper reports the generation of stable transgenic dwarf cuttlefish expressing fluorescent proteins using CRISPR and transposons, enabling live imaging of cell dynamics during embryonic development.

The paper constructs a high-density linkage map in allotetraploid peanut to study double reduction, finding it occurs in 12% of progenies and contributes to genomic imbalance and genetic instability.

The paper introduces Dynema, a method for genome-wide mapping of context-dependent and independent eQTLs at single-cell resolution, showing improved detection compared to pseudobulking approaches.

This study shows that biases in rescaling forward-in-time population genetic simulations can be reduced by using a different simulation algorithm.

The paper identifies genes modulating stress-induced sleep in C. elegans using automated screening and genetic association analysis.

This study evaluates adherence to NASEM recommendations on population descriptors in GWAS papers using a large language model-based toolkit, finding improvements over time but limited impact post-report publication.

This study compares dyadic and marginal models for analyzing social interaction traits, showing that dyadic models better estimate genetic and environmental effects while marginal models can introduce bias.