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The paper uses extreme QTL mapping in Drosophila to identify genetic loci associated with zinc toxicity resistance, finding seven QTL and ten genes with genotype-by-treatment effects.

The paper introduces CBA, a probabilistic method to infer genetic and growth rates from cell populations, using a backbone tree and monogram to model evolutionary processes.

This study evaluates LLMs for gene-to-phenotype mapping, finding that models with dedicated databases achieve >80% accuracy and provide supporting literature.

This study examines how different TTC7A missense mutations in pediatric IBD patients lead to distinct intestinal epithelial phenotypes.

This paper develops an iPSC-derived iMSC model of Osteogenesis Imperfecta that recapitulates disease phenotypes and enables drug screening.

This paper combines eDNA and acoustic-trawl data using a Bayesian joint model to estimate fish biomass, showing eDNA suggests broader distribution and potentially higher abundance of European anchovy.

This study uses Drosophila models to identify phospholipid and sphingolipid abnormalities in peroxisomal biogenesis disorders, revealing substrate channeling effects on lipid acyl chain lengths.

The paper develops a model to predict biological age from physiological traits, identifies factors influencing aging, and links {Delta}Age to mortality risk.

The paper analyzes gene expression variation in C. elegans across strains to reveal cis and trans regulatory effects and stabilizing selection on expression levels.

This study analyzes 156 genomes from the Sarmatian period in the Carpathian Basin, revealing East Asian ancestry and two unknown migration waves, with continuity into the Hunnic period.

This paper introduces a mathematical framework to classify, quantify, and compare genetic buffering relationships between genes using a ratio scale and a novel 'parallel' model.

This paper presents a high-quality genome assembly for the sea star Linckia laevigata and describes its genomic features.

This study investigates the role of juvenile hormone degradation enzymes in Drosophila development, revealing shared and unique requirements for JHE and JHEH in regulating developmental timing and growth.

The paper generates two novel D2hgdh loss-of-function mutations in Drosophila to study D-2HG accumulation and its effects on development and metabolism.

The paper identifies PALS-22 as a regulator of AGO expression in C. elegans, showing its role in balancing immunity and germline health through modulation of RNAi and epigenetic inheritance.

RetiGene provides a curated gene atlas for inherited retinal diseases, integrating variant data and RNA sequencing to support gene prioritization and therapeutic development.

The paper introduces diplo-locus, a Python toolkit for simulating and inferring parameters from time-series genetic data under diploid selection models.

CACTI improves cQTL mapping by using correlations between regulatory elements, identifying more signals and colocalizing with GWAS loci better than traditional methods.

The paper develops a framework to estimate genetic and social homogamy using family data and finds that indirect assortative mating better explains educational attainment similarities than direct assortment.

This study tests a homing gene drive in Drosophila melanogaster and finds that while simple resistance alleles can emerge, complex resistance is unlikely due to no heritable genetic effects on drive efficiency.