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363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- GeneticsbioRxivPreprint
DNA barcoding affirms the presence of invasive Parachanna obscura and new records of some species in the Mweru-Luapula fishery
Bornwell Seemani, Cyprian Katongo, Paulette Bloomer…·Carel J. Oosthuizen
This study uses DNA barcoding to identify native and invasive fish species in the Mweru-Luapula fishery, confirming the presence of Parachanna obscura and discovering new species records.
DOI 10.1101/2024.02.11.579834 - GeneticsHeredityPeer-reviewed
Investigating pedigree- and SNP-associated components of heritability in a wild population of Soay sheep
Caelinn James, Josephine M. Pemberton, Pau Navarro, Sara Knott
The paper applies a method to estimate heritability in a wild sheep population, finding that including an identity-by-descent GRM improves model fit for polygenic traits but not monogenic ones.
- GeneticsbioRxivPreprint
Natural variation in infection specificityof Caenorhabditis briggsae isolates by two RNA viruses
Cigdem Alkan, Gautier Brésard, Lise Frézal…·Marie‐Anne Félix
The paper investigates natural variation in C. briggsae isolates' resistance to two RNA viruses, identifying genomic regions associated with viral resistance.
DOI 10.1101/2024.02.10.579610 - GeneticsBiostatisticsPeer-reviewed
Mendelian Randomization Analysis Using Multiple Biomarkers of an Underlying Common Exposure
Jin Jin, Guanghao Qi, Zhi Yu, Nilanjan Chatterjee
This paper introduces MRLE, a method for Mendelian Randomization analysis of latent exposures using multiple biomarkers, showing improved power and evidence for inflammation's causal role in diseases.
- GeneticsbioRxivPreprint
Insights from Genetic Studies: SNP Analyses Confirm White Clover Naturalization in Brazil
Amanda S. Alencar, Yoshishisa Suyama, Daiki Takahashi…·Catarina Fonseca Lira
This study uses SNP analysis to show that white clover populations in Brazil have high within-population genetic diversity, with some populations showing admixture with cultivars and others having distinct genetic backgrounds, confirming its naturalization.
- GeneticsbioRxivPreprint
A genome wide search for non-additive allele effects identifies PSKH2 as involved in the variability of Factor V activity.
Blandine Gendre, Ángel Martínez-Pérez, Marcus Edi Kleber…·David‐Alexandre Trégouët
The paper identifies PSKH2 as a gene influencing variability in Factor V plasma activity through genome-wide analysis of non-additive allele effects.
DOI 10.1101/2024.02.08.579474 - GeneticsbioRxivPreprint
Using machine learning to integrate genetic and environmental data to model genotype-by-environment interactions
Igor Kuivjogi Fernandes, Caio Canella Vieira, Kaio Olímpio das Graças Dias, Samuel B. Fernandes
This paper integrates environmental data with genetic data using machine learning to improve genomic prediction models for maize grain yield, showing increased predictive ability and computational efficiency.
- GeneticsbioRxivPreprint
Determining susceptibility loci in triple negative breast cancer using a novel pre-clinical model
Samson Eugin Simon, Boston W. Simmons, Minjung Kim…·Liza Makowski
The paper develops a novel murine model to identify genetic modifiers of triple-negative breast cancer traits and identifies susceptibility loci with potential translational relevance.
DOI 10.1101/2024.02.08.579359 - GeneticsbioRxivPreprint
Developmental disruption of the mitochondrial fissiongene drp-1 extends the longevity of daf-2 insulin/IGF-1 receptor mutant
Annika Traa, Jeremy M. Van Raamsdonk
This study shows that disrupting the mitochondrial fission gene drp-1 during development extends the lifespan of daf-2 mutants by improving mitochondrial function and stress resistance.
2 citations - GeneticsJournal of Experimental BotanyPeer-reviewed
Genetic mapping reveals new loci and alleles for flowering time and plant height using the double round-robin population of barley
Francesco Cosenza, Asis Shrestha, Delphine Van Inghelandt…·Benjamin Stich
15 citations - GeneticsbioRxivPreprint
Loss of function in RBBP5 results in a syndromic neurodevelopmental disorder associated with microcephaly
Yue Huang, Kristy L. Jay, Alden Yen-Wen Huang…·Julián A. Martínez-Agosto
The paper identifies de novo RBBP5 variants in individuals with neurodevelopmental disorders and shows they cause loss of function through structural and Drosophila model analyses.
2 citations - GeneticsbioRxivPreprint
Dominant suppressor genes of p53-induced apoptosis in Drosophila melanogaster
Tamás Lukácsovich, Tamás Szlanka, Éva Bálint…·István Kiss
The paper identifies seven genes in Drosophila melanogaster that suppress p53-induced apoptosis through insertional mutagenesis using the DEP transposon.
DOI 10.1101/2024.02.06.579196 - GeneticsLife Science AlliancePeer-reviewed
Chromatin states contribute to coordinated allelic transcriptional bursting to drive iPSC reprogramming
Parichitran Ayyamperumal, Hemant Chandru Naik, Amlan Jyoti Naskar…·Srimonta Gayen
The paper investigates how chromatin states influence coordinated allelic transcriptional bursting during iPSC reprogramming and finds that chromatin accessibility correlates with allelic coordination.
- GeneticsbioRxivPreprint
Self-regulation of the DNA N6-adenine methyltransferase AMT1 in the unicellular eukaryote Tetrahymena thermophila
Lili Duan, Haicheng Li, Aili Ju…·Yuanyuan Wang
This study identifies a self-regulatory mechanism of the 6mA methyltransferase AMT1 in Tetrahymena thermophila, showing that AMT1 modulates its own transcription through 6mA methylation and affects cell fitness.
- GeneticsbioRxivPreprint
Rtt107 cooperates with Rad55 or Slx4 to maintain genome stability in Saccharomyces cerevisiae
Joshua A.R. Brown, Michael Steffen Kobor
This study identifies Rtt107's role in preventing genome instability by interacting with Rad55 and Slx4, showing distinct functions in limiting crossover events and maintaining rDNA stability.
DOI 10.1101/2024.02.05.579050 - GeneticsbioRxivPreprint
Genetic architecture and adaptation of Ladakh highlanders of trans-Himalayas
Lomous Kumar, Richa Rajpal, Bhavna Ahlawat…·Niraj Rai
This study genotypes 80 Ladakh individuals to analyze genetic lineages, admixture, and adaptation, finding distinct East Asian and Indo-European affinities with signals of high-altitude and immunity adaptation.
5 citations - GeneticseLifePeer-reviewed
Chromosome Structure I: Loop extrusion or boundary:boundary pairing?
Xinyang Bing, Wenfan Ke, Miki Fujioka…·James B. Jaynes
This study tests two models for TAD boundary formation in flies and finds that boundary pairing, not loop extrusion, determines TAD endpoints.
25 citations - GeneticsGeneticsPeer-reviewed
An expression-directed linear mixed model (edLMM) discovering low-effect genetic variants
Qing Li, Jiayi Bian, Yanzhao Qian…·Quan Long
This paper introduces edLMM, a method that detects low-effect genetic variants using moderate sample sizes, improving missing heritability estimation.
- GeneticseLifePeer-reviewed
Chromosome Structure II: Stem-loops and circle-loops
Wenfan Ke, Miki Fujioka, Paul D. Schedl, James B. Jaynes
The paper investigates how loop topology in Drosophila TADs affects physical and regulatory landscapes by replacing boundaries and analyzing the resulting structural and functional changes.
13 citations