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The paper introduces AlphScore, a pathogenicity prediction score for missense variants using AlphaFold2-derived features, showing improved performance when combined with existing scores.

The paper identifies conserved notochord-specific enhancers of Brachyury/T/TBXT in vertebrates and shows their role in notochord expression and development.

This study shows HRDE-1 promotes heterochromatin silencing and small-RNA amplification in C. elegans, establishing a self-enforcing mechanism for transgenerational silencing.

This study identifies sequence requirements for CRISPR-associated transposon DNA integration using mutagenesis libraries and reveals a novel role for IHF in transposition.

This study maps agronomic trait genetics and identifies selection signatures in faba bean germplasm using genome-wide association studies and population structure analysis.

This study shows that using cryopreserved semen from an old bull helped restore genetic diversity in a cattle breed without increasing inbreeding and improved reproductive performance.

The paper shows that MDT-15 is essential for activating propionate shunt pathway genes in C. elegans, preventing embryonic lethality by regulating vitamin B12-dependent gene expression.

The paper shows that template-switching mutations generate over 6,000 hairpin structures in primates, leading to 18 new human miRNA genes, 26% of which emerged since primates originated.

This paper introduces a bivariate GWAS approach to uncover hidden genetic loci in Arabidopsis thaliana by addressing population stratification and identifies a pleiotropic gene affecting flowering time and maturation.

DeMAG improves variant classification by integrating structural and evolutionary epistatic features, reducing false positives and improving accuracy for clinically actionable genes.

The paper reanalyzes data from Shen et al. to argue that most synonymous mutations in yeast genes are not deleterious, challenging their original conclusions about fitness effects.

The paper compares the neutrophil response to Mycobacterium tuberculosis infection between HIV+ individuals with and without TB history, finding distinct gene expression and NETosis patterns in those without TB.

The paper investigates how different PUM1 mutations lead to distinct phenotypes by analyzing PUM1 interactomes and showing that dosage sensitivity involves non-linear mechanisms.

This study identifies a reduction in ER chaperones in PWS β-cells, leading to impaired insulin secretion and ER stress.

The paper develops a CRISPR/Cas9-mediated knock-in method in African turquoise killifish for precise genomic modifications and cell-type-specific expression.

The paper investigates E. bieneusi prevalence in cats and dogs in Shanghai, finding genotype D, a zoonotic pathogen, in 9.5% of samples with higher rates in stray animals.

The paper uses haplotype and QTL analysis in diploid potato breeding to identify and fix favorable alleles for developing inbred-hybrid varieties.

The paper evaluates strategies for deploying insecticides to minimize resistance, finding that mixtures remain most effective when insecticides are fully effective.

The paper uses genetic analysis to identify a confiscated bird as a Bornean subspecies instead of a Seychelles species, highlighting the importance of genetics in wildlife crime investigations.