Discover, rate, and discuss biology preprints.

This paper extends a method to infer temporally variable selection from ancient DNA data, accounting for linkage and epistasis, and applies it to horse pigmentation loci.

The paper introduces the hidecan R package for visualizing GWAS and differential expression results along with manually curated candidate genes.

The paper reports mtDNA d-loop diversity in Albanian Prespa dwarf cattle, identifying high diversity and haplogroups T3 and T1, suggesting a complex female genetic history.

This paper develops a CRISPR-guided transposon system for DSB-free DNA integration in human cells, improving efficiency and reducing off-target effects.

This study uses genomic PCA to identify shared genetic architecture between brain morphometry, ageing, and cognitive ability using UK Biobank data.

The paper develops ChoruMM, a multi-components mixed model for bacterial GWAS, showing that standard human genetics models are inadequate for highly structured bacterial genomes.

The paper examines how genetic ancestry influences gene expression and DNA methylation in admixed African/Black Americans, showing environmental and genetic factors affect brain disease risk.

The paper identifies ZYX-1/zyxin as a key protein linking actomyosin networks to cell-cell junctions during apical constriction in C. elegans gastrulation.

The paper identifies N6-methyldeoxyadenosine (6mA) as an epigenetic mark in C. elegans mtDNA, showing its dynamic regulation and link to mitochondrial function.

This study shows that preselecting QTL markers improves genomic selection accuracy for oligogenic traits in Norway spruce, but not for polygenic traits.

The paper investigates the expansion and functional diversification of chitinase and chitin synthase genes in Atlantic salmon using comparative genomics, transcriptomics, and chromatin accessibility data.

The paper describes a method for isolating high-quality single nuclei from postmortem human heart tissue for DNA and RNA analysis, including quality control measures.

This paper introduces a new split-Gal4 system based on a self-excising split-intein that is fully repressible by Gal80, enabling temporal control of genetic labeling in Drosophila.

The paper investigates the replication of genetic effects on wing shape in Drosophila melanogaster using artificial selection and bulk segregant analysis, finding shared genetic responses but limited replication in natural populations.

The paper infers germline CpG methylation signatures in the human population using polymorphism data and a new method, achieving high concordance with WGBS data while capturing previously missed CpG sites.

The paper analyzes genetic and phenotypic data from 4,145 Russians to explore ethnic diversity and genetic associations, finding enrichment of Finnish-specific variants and providing a GWAS database.

The paper quantifies how mitochondrial network structure influences mtDNA variability during cell divisions and identifies mechanisms to control heteroplasmy variance.

The paper introduces a maximum likelihood approach to analyze mtDNA heteroplasmy data, showing that traditional statistics can lead to false positives in detecting selection and bottleneck effects.

This study compares genomic selection strategies in clonal plant breeding, finding that selecting parents based on genomic predicted cross performance leads to faster genetic gain and reduced inbreeding.

This study integrates multi-omics data from mouse embryonic stem cells to identify genetic drivers of proteome variability and uncover regulatory mechanisms in pluripotency.