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This paper presents a near-complete lamprey genome assembly, revealing gene family expansions and regulatory elements linked to vertebrate innovations.

This study uses single-cell and spatial profiling to identify cellular and molecular drivers of beta cell dysfunction in the pancreas of cystic fibrosis patients.

The paper presents T2T reference genomes from a multi-generational pedigree to study genetic and epigenetic inheritance across the complete genome.

This study analyzes eight high-coverage Jomon genomes to reveal genetic continuity and phenotypic traits of ancient Japanese hunter-gatherers, showing their genetic influence on present-day Japanese populations.

This paper introduces a pooled CRISPR screening platform combined with self-supervised deep learning to infer gene function from morphological phenotypes without target-specific biomarkers.

The paper identifies trans-acting genetic variation that regulates 3D chromatin interactions through heterochromatin formation, showing how this mechanism coordinates chromatin state and gene expression changes.

This study evaluates how admixture, selection, and demographic history influence GWAS power and fine-mapping precision in admixed populations using simulations and empirical data.

The paper uses single-cell multiomics to study B cell changes in mice during malaria reinfection, finding shifts in memory B cell composition and epigenetic programs linked to rapid antibody production.

The paper investigates why many GWAS loci linked to immune-mediated diseases lack eQTL colocalization by analyzing chromatin accessibility QTLs in LCLs and other immune cell types.

This study uses transcriptomic profiling and machine learning to uncover regulatory complexity in mitochondrial gene expression in severe Plasmodium vivax malaria, highlighting the role of natural antisense transcripts.

This study benchmarks six duplex sequencing technologies to evaluate their performance in detecting somatic mutations across different genomic contexts and tissue types.

The paper provides the first direct evidence of transcription from germline-restricted chromosomes (GRCs) in fungus gnats, identifying expressed genes and a horizontally acquired bacterial region.

The paper uses Nanopore long-read DNA sequencing to analyze retrotransposon activation in aged and Alzheimer's disease brains, identifying somatic insertions and epigenetic changes.

The paper identifies epistatic interactions between cancer driver mutations and allele-specific copy number variations in tumors, showing their impact on patient survival.

The paper analyzes over 2,000 Caenorhabditis briggsae wild strains to uncover genetic diversity, population structure, and evolutionary mechanisms shaping phenotypic variation.

The paper examines the effects of forest fragmentation on genetic diversity and demographic structure of the critically endangered tree species Dinizia jueirana-facao, finding reduced pollen dispersal distances and no evidence of inbreeding or genetic diversity loss.

The paper introduces cfRNA-ICL, a model trained on synthetic data generated from a biologically grounded SCM, showing improved performance in cancer classification tasks compared to generic models.

TissueCraftAI generates multi-modal spatial omics data from histology images using natural language prompts, outperforming existing methods in image generation and molecular data prediction.

The paper identifies thousands of alternative splicing events in human vascular endothelial cells under hypoxia, revealing a more complex and dynamic transcriptional response than conventional RNA-seq suggests.