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This paper introduces end-to-end genomic prediction to directly predict images and text from genetic markers, showing comparable accuracy to traditional numeric phenotype-based methods.

This paper develops a pooled paired prime editing screen to generate large-scale deletions across the genome, identifying non-coding regions with fitness effects and demonstrating the feasibility of genome-wide deletion perturbation.

This study performs a multi-ancestry transcriptome-wide association study (TWAS) to identify shared and population-specific genetic effects in Alzheimer's disease using RNA-seq and genotype data from multiple cohorts.

The paper analyzes single-stranded DNA (ssDNA) formation in human and non-human ape telomere-to-telomere genomes to identify non-B DNA structures and their functional roles.

The paper presents a multi-tissue sheep atlas identifying regulatory variants and their effects on molecular phenotypes, revealing allelic heterogeneity and evolutionary patterns.

The paper identifies genetic modifiers of Hirschsprung disease severity using a mouse model and multiomic analysis of the Enteric Nervous System.

The paper uses whole-genome data from tinamous to reconstruct their phylogeny, estimate divergence times, and assess the impact of incomplete lineage sorting and introgression on genome evolution.

The paper presents a chromosome-level genome assembly for wild alpine reindeer and improves the assembly for Svalbard reindeer, providing gene annotations and comparisons with prior assemblies.

MERFISH+ enables high-resolution spatial multi-omics mapping of gene expression and chromatin organization in developing human hearts with subcellular resolution.

This study investigates Amoebic Gill Disease (AGD) in Atlantic salmon using a holo-omic approach, linking host genetics, microbiota, and disease resistance traits.

The paper identifies cryptic genetic diversity in Pacific herring, showing a biogeographic break linked to glacial cycles.

The paper presents a global virome atlas, UHGV, and identifies genomic factors influencing phage-host interactions.

This study uses nanopore long-read sequencing to analyze genomic disruptions in Alzheimer's disease, finding increased retrotransposon activity and structural variants in aged brains.

The paper benchmarks human read removal methods in metagenomics, finding that high-sensitivity Bowtie2 with T2T-CHM13 reference improves removal while preserving microbial data.

The paper generates genome assemblies for ten brood parasitic bird species and their outgroups, enabling comparative genomic analyses of obligate brood parasitism evolution.

The paper improves click-code-seq for mapping DNA oxidation and depurination in human genomes, revealing strand bias in oxidized guanines and apurinic sites.

The paper analyzes over 800,000 human genomes to assess penetrance of clinically relevant variants, finding that 95% of pLoF variants in severe diseases have explanations for lack of disease manifestation.

The paper uses single-cell DNA sequencing to analyze somatic mosaicism in postmortem lung and colon tissues, revealing mutation heterogeneity, chromosomal abnormalities, and cellular ancestry.

This study identifies de-novo generation of ancestral horned variants in cattle through distinct recombination events at the POLLED locus, highlighting genetic complexity in polledness.

This study uses single-nucleus multi-omics to identify sex-specific transcription factor motifs linked to chromatin accessibility and MASLD in mouse liver.