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Topsicle estimates telomere length from whole genome long-read sequencing data using k-mer and change point detection, showing robustness and accuracy in plant and human cancer cells.

The paper assesses genetic diversity of soil-transmitted helminths across regions and evaluates its impact on molecular diagnostic targets using low-coverage genome sequencing and in vitro assays.

The paper tests regulatory potential of conserved enhancers in thylacine and wolf to assess functional convergence over 160 million years of evolution, finding limited evidence of convergent divergence.

The paper uses long-read sequencing to analyze telomere-to-telomere assemblies in Populus trichocarpa, revealing complex KCS gene variation and its association with helitron transposons.

This study analyzes 114 C. fetus genomes to explore genetic diversity, antimicrobial resistance, and zoonotic potential across hosts and geographies.

This paper develops a hybridization capture method to enrich mitochondrial genomes of soil-transmitted helminths from fecal samples, achieving high enrichment and sensitivity.

The paper measures SLC6A6 mRNA expression in lymphoblastoid cell lines from Alzheimer's disease patients and finds it is 2.8-fold lower than in age-matched controls, suggesting a potential role for taurine in AD pathogenesis.

The paper describes the gene model for the ortholog of Glycogen synthase in Drosophila ananassae as part of a dataset for studying IIS pathway evolution.

The paper expands the DNA motif lexicon of transcriptional regulatory code by identifying composite elements and using a deep learning model to predict their activity and impact of variants.

This study identifies genes associated with monogermity and betalain biosynthesis in sugar beet through genome-wide association analysis of 290 accessions.

This study identifies novel protective genetic variants associated with TMT-B performance using a family-based GWLS approach in the Long Life Family Study.

This study investigates how TB and COVID-19 co-infection affects the sputum microbiome, finding altered bacterial abundance and functional pathways that may impact treatment outcomes.

This study examines differences between Infinium MethylationEPIC v1 and v2, showing high array-level concordance but probe-level variation, and recommends accounting for version differences in analyses.

The paper investigates TICRR/TRESLIN and MTBP chromatin binding in human cells, showing G1-specific dependency on TRESLIN and independence from licensed origins.

The paper presents the first high-quality genome assembly for the White-bellied Sholakili, using Nanopore and Illumina data, and reports its completeness and functional annotations.

The paper tests if genetic load proxies predict fitness better than inbreeding in a wild population and finds inbreeding metrics perform better.

This study identifies DNA methylation loci associated with heart failure in mice, showing their functional relevance and therapeutic potential through in vitro and in vivo experiments.

The paper presents the de novo genome assembly of the hibiscus mealybug, Nipaecoccus viridis, and reports gene count and repetitive element composition.

The paper builds a reference genome for Cylicocyclus nassatus, estimates its genetic diversity across regions, and identifies genetic candidates for pyrantel resistance.

The paper introduces scDEEP-mC, a single-cell DNA methylation profiling method, and shows it can identify cell types, X-inactivation states, and replication dynamics with high coverage.