Discover, rate, and discuss biology preprints.

This study investigates how hypernatremia affects action potential duration in a mouse model of long QT syndrome type 3, finding that it increases transient outward potassium currents and alters repolarization patterns.

This study examines how neural control and mechanical demands affect energy use in skeletal muscle during dorsiflexion contractions.

This study investigates how CDO1-mediated cysteine catabolism in hepatocytes and adipocytes affects diet-induced obesity and fatty liver in mice, finding differential impacts based on tissue-specific manipulation.

This study evaluates alternative pacing methods for assessing AVNRT inducibility using a rabbit AV node model, finding they reduce misestimation and improve separation between echo beats and sustained reentry.

This study identifies trimethylamine (TMA) as a microbial compound that inhibits IRAK4, reducing inflammation and improving metabolic outcomes in high-fat diet conditions.

The paper describes a new symbiotic system called semilichens, intermediate between green biofilms and lichens, showing algae-fungal interactions and carbon transfer.

The study finds that larger ants in Messor barbarus are more sensitive to temperature changes than smaller ants, which may influence their foraging activity timing and colony responses to warming.

This study examines how food deprivation affects cart gene expression in Nile tilapia and gilthead seabream, revealing species-specific responses in brain regions.

The paper identifies multiple cart genes in two fish species, analyzes their structure and expression, and highlights their complexity compared to mammals.

This study shows that neddylation regulates mitochondrial dynamics and turnover in the adult heart, linking its disruption to cardiomyopathy and heart failure.

This study investigates the role of Tmem63b in mouse voiding behavior by deleting it in urothelial and sensory neuron tissues, finding no significant impact on voiding behavior.

This study shows PARP1 deficiency causes aging-related cardiac failure by activating Akt signaling, leading to hypertrophy and fibrosis in mice.

This study shows that increased CPT1a expression protects the heart from pathological stress by suppressing harmful gene programs, and gene transfer can rescue cardiac function in disease models.

This study shows CO2 passes through human AQP1 via both monomeric pores and a novel DIDS-sensitive pathway, while NH3 primarily uses the monomeric pores.

This study identifies a shared molecular signature in adipose tissue dysfunction across obesity and lipodystrophy, revealing common metabolic pathways and genetic loci associated with type 2 diabetes.

The paper identifies a novel pacemaker activity in Drosophila midgut called superstalsis, linked to specific muscle activation and gene expression under physiological conditions.

The paper assesses climate factors' associations with chickpea yield and identifies spatial probabilistic patterns of heat and water stress in Australia, showing increased stress frequency with climate change.

This study examines if pre-training bone characteristics predict changes in lean tissue mass after resistance training, finding little association.

This study examines age-related and sex-dependent cardiac dysfunction in Microcebus murinus by analyzing heart rate and variability under stress and autonomic modulation.

This study investigates how insect body size and mouth size influence microplastic ingestion and breakdown, finding that crickets consume plastics when particles can be whole-consumed and break down larger MPs as they grow.