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This study investigates changes in carotid body mitochondrial function in heart failure, finding decreased oxygen affinity and increased oxidative stress.

This study investigates age-related changes in protein insolubility in skeletal muscle and shows that these changes are sex- and compartment-specific and can be modified by exercise and rapamycin.

The paper quantifies and visualizes aerodynamic rebreathing in infants during prone sleep, showing how anatomical and environmental factors influence this hazard.

SPARK infers latent cardiac autonomic dynamics from RR intervals, showing physiological information reduces solution variability and reveals distinct autonomic responses.

This study shows that haemoglobin from haemolysed plasma interferes with bioluminescence assays in ciPTECs, but does not severely injure the cells.

This study examines trunk muscle activity in centipedes during different locomotion patterns, finding that the same muscles serve contrasting roles in generating undulation or straightening the trunk.

This study shows that satellite cell glucocorticoid receptor (GR) maintains quiescence but does not mediate therapeutic GC effects on muscle repair, highlighting the importance of treatment timing and context.

This study identifies middle ear dysfunction as the primary cause of residual hearing loss in chronically implanted guinea pigs, suggesting a conductive mechanism.

This study investigates how cardiac arrest affects myocardial ribosome biology and protein synthesis in pigs and mice, finding increased ribosomal transcripts with ischemic burden and suppressed ribosome activity post-arrest.

This study examines the effects of isocaloric high-fat diet restriction with TAK-242 on metabolic and gut microbial responses in mice, finding limited normalization of adiposity and microbial community.

This study shows that Trichostatin A, an HDAC inhibitor, reduces muscle atrophy and preserves nuclear organization in mice subjected to mechanical unloading.

This study examines sex differences in muscle volume, strength, and motor unit properties during bed rest and retraining in young males and females, finding no sex differences in strength loss but greater MU firing rate reduction in females.

This study shows that northern juvenile Chinook salmon have high thermal tolerance and plasticity, with warm acclimation improving heat tolerance and cardiac function.

This study develops a method to culture human pediatric cardiac tissue slices for extended periods, enabling functional and pharmacological testing of cardiac physiology.

This study examines how Clcn7 mutations in mice affect bone phenotypes, showing increased trabecular bone mass with variations based on age, sex, genetic background, and mutation type.

The paper examines how food and water intake patterns in rats change under light phase restrictions, finding that food access timing more strongly influences water intake than water access timing influences food intake.

The paper shows serotonin signaling spatially controls nutrient-responsive midgut turnover in Drosophila by regulating enteroblast maturation and morphological changes through the 5HT7 receptor.

This study identifies an mTORC1-PWP1-Hedgehog circuit that links nutrient metabolism to intestinal stem cell differentiation in Drosophila, showing its role in aging and tissue renewal.

This study shows that transient ATF4 activation in neurons during early adulthood extends healthspan and promotes systemic adaptations in Drosophila.

This study investigates how partial agonists affect desensitization in KARs, showing that agonist residence time and LBD closure are more critical than subunit composition in heteromeric receptors.