Discover, rate, and verify biology preprints.

The paper analyzes Xanthomonas campestris strains from weed and crop hosts to show that mobile genetic elements accompany the emergence of clonal crop lineages and are present in diverse weed-associated strains.

This study examines how basolateral amygdala neuron activity changes during punishment learning in mice, showing that punishment learning alters action-related activity to align with punisher-specific responses.

This study investigates how perceptual sensitivity and errors contribute to locomotor adaptation, finding that sensitivity drives initial motor corrections while errors predict motor aftereffects.

This study shows TMEM106B C-terminal fragment aggregation synergizes with α-synuclein and TDP-43 to worsen neurodegeneration in C. elegans, but not with tau.

The paper identifies genomic signatures of fluctuating selection in rock ptarmigan populations over an 11-year period, showing allele frequency changes correlated with demographic cycles.

The paper compares protease-inhibitor gene family counts across species, showing how annotation methods and counting units affect results.

The paper identifies an effective broad-spectrum inhibitor of archaeal nitrification through soil-based structure-activity relationship analysis.

The paper uses deep mutational scanning to study pleiotropic effects in rhodopsin, revealing how mutations impact multiple molecular phenotypes and shape light sensitivity.

This study uses fMRI to compare brain activation during a cognitive task between pediatric cancer survivors exposed to chemotherapy and healthy controls, finding altered neural activation and cognitive control deficits in the chemo-exposed group.

This study develops live-cell CHIKV reporter systems to analyze cell-type-dependent antiviral responses to ribavirin, revealing differences in antiviral efficacy across cell models.

The paper develops deep learning models to predict transcription initiation patterns from DNA sequences across human tissues and cancers.

This study shows that inhibiting HuR with SRI-42127 reduces neuroinflammation and secondary injury after TBI, improving functional outcomes in mice.

This study uses patient-derived iSMCs to uncover new mechanisms of PAH and sotatercept's effects beyond its known anti-proliferative actions.

The paper introduces FICTURE2, a statistical model that infers transcriptional programs from individual RNA molecules in spatial transcriptomics data, revealing spatial organization and cellular identity without segmentation.

This study reanalyzes longitudinal serum proteomics data from tuberculosis patients to assess how nutritional-metabolic recovery during treatment varies by baseline BMI, finding no significant BMI-dependent trajectories but an overall increase in a 36-protein summary axis.

The paper demonstrates that motors can shepherd diffusive proteins on microtubules through biased diffusion, revealing a mechanism for spatial patterning without direct binding.

This study develops a high-resolution 23Na-MRI platform using implanted RF coils to detect ischemic brain injury with improved contrast-to-noise ratio.

This study examines KoRV profiles in koalas from the Snowy Monaro region, finding lower viral loads and unique subtype distributions compared to northern populations.

The paper investigates how many mutations are needed to evolve a new function using a Boolean-network model of genotype-phenotype maps, showing a power-law scaling with network size.

This study shows that knocking down DNAAF3-AS1 reduces gene-body H3K36me3, activates the p53 pathway, and alters promoter usage in apoptosis-related genes.