Xin Yu

This study develops a high-resolution 23Na-MRI platform using implanted RF coils to detect ischemic brain injury with improved contrast-to-noise ratio.

This study develops photoswitchable nanovesicles for controlled in vivo neuropeptide delivery, showing they modulate hippocampal circuit dynamics and social behavior in mice.

The paper analyzes vasomotor rhythms in awake mice using fMRI to show their multiscale propagation patterns across the cortex.

This paper introduces an ultra-high-resolution MRI framework to map perivascular spaces (PVS) across the whole brain, revealing their hierarchical organization along vascular trees.

This paper introduces NARS-fMRI, a method that detects millisecond neuronal activity via 23Na signal changes, showing it correlates with BOLD and glutamate transients in rodent somatosensory cortex.

This study shows that smooth muscle dysfunction caused by ACTA2 mutations leads to cerebrovascular reserve failure, increasing brain vulnerability to hypoperfusion and injury.

This paper develops a wireless system for simultaneous EEG and fMRI recording, demonstrating its ability to capture neurovascular coupling in the somatosensory cortex.

This study shows that unilateral carotid artery stenosis reduces interhemispheric BOLD coherence at ~0.1 Hz, especially in watershed areas, suggesting impaired vasomotor activity affects resting-state functional connectivity.

This study shows that mild perinatal hypoxia-ischemia causes delayed and prolonged neuronal death, with neurons dying later showing normal function and viability for days post-injury.

This paper develops a high-resolution awake mouse fMRI platform to map sensory processing in association cortices, revealing anticipatory brain activity during vibrissa stimulation.

This study uses high-resolution MRI to map glymphatic transport in deep brain regions by directly infusing Gd into the lateral ventricle and analyzing PVS signal enhancements.

The paper assesses consistency of rat fMRI results across 12 centers using a unified pipeline and identifies variability due to experimental differences.

The paper develops a deep learning-based method to segment micro-vessels from CBV MRI images of AD mice, revealing region-specific vascular density changes in degenerated brains.

This paper introduces radial encoding MRI to achieve high spatiotemporal resolution single-vessel fMRI in rat somatosensory cortex, enabling detailed hemodynamic mapping of microvessels.

The paper attempts to replicate DIANA fMRI findings in anesthetized mice but fails to observe direct neuronal activity-like peaks, suggesting potential artifacts or data pre-selection issues.

This study examines the relationship between cerebrovascular reactivity and age/sex effects in brain activity, finding limited impact of correcting for reactivity on these effects.

The paper uses pupillary light response-driven fMRI in awake mice to identify brain-wide biomarkers of Alzheimer's disease by analyzing altered neuromodulatory patterns and functional connectivity.

This study combines 14T single-vessel MRI and optical microscopy to map cerebral blood flow velocity in mouse brain microvessels, validating measurements across modalities.

This paper develops a data-driven method for analyzing fMRI data across studies, revealing consistent patterns in BOLD time series and demonstrating its generalizability and robustness.

This paper introduces a new fMRI method called SELINE to improve laminar-specific BOLD signal detection by reducing vein effects and improving spatial resolution.

This paper introduces inductively-coupled ear-bars (ICEs) to enhance fMRI signal in rat entorhinal cortex, achieving a 2-fold SNR increase and enabling better connectivity mapping.

This paper develops a multi-slice line-scanning fMRI method to map laminar-specific functional connectivity in anesthetized rats, revealing trial-dependent and layer-specific spatiotemporal patterns of BOLD responses and resting-state signal propagation.

This paper develops an implantable inductive coil detector to enhance focal fMRI signal sensitivity in animal brain imaging, achieving a 2-3 fold increase in tSNR compared to conventional methods.

The paper investigates the relationship between lateral hypothalamic activity and pupil dynamics across different brain states, finding that LH activity modulates the correlation between pupil dynamics and ACC signals.

This paper introduces CBF-fMRI using phase-contrast imaging to map blood velocity in single vessels, showing comparable velocity changes in arterioles and venules.

The paper identifies trial-specific brain state patterns linked to pupil dynamics in anesthetized rats using PCA and decoding methods.

This paper develops a bilateral line-scanning fMRI method to map laminar-specific interhemispheric connectivity in rodents, revealing layer-specific coherence patterns in the corpus callosum.

This paper uses echo-state networks to predict rs-fMRI signal fluctuations from vascular dynamics in rodent and human brains, revealing brain states with global synchrony and decoupled internal correlations.

This study uses optogenetic activation of the corpus callosum to map brain-wide network effects using fMRI and calcium recording.