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The paper introduces SMFNet and PRISM to analyze how transcription factor assemblies influence chromatin accessibility and identifies sequence-encoded principles of combinatorial TF assembly.

This study examines how rising water temperatures affect IHNV replication and host-pathogen interactions, identifying thermotolerant isolates and validating zebrafish larvae as a model for virulence assessment.

This study reveals that the ISG Shiftless (SHFL) has both antiviral and proviral functions during coronavirus infection, enhancing susceptibility while modulating IFN signaling.

This study identifies Mln1 as a regulator of metabolic flexibility and thermotolerance in Cryptococcus neoformans, revealing a trade-off between nutrient utilization and stress resistance.

The paper shows that the plasmid pAB3 integrates into the chromosome of Acinetobacter baumannii ATCC 17978, leading to chromosomal rearrangements and potential phenotypic changes.

DCAF improves single-cell perturbation simulation by addressing data, evaluation, and model validity, outperforming baselines in generalization and recapitulating regulatory heterogeneity in mouse brain.

The paper investigates the molecular evolution of grey coat color in cattle and identifies MC1R residue 223 as a recurrent target for coat-color lightening in both domestic and wild bovids.

In Dp16 Down syndrome mice, MRI shows reduced cerebral blood flow and oxygen metabolism (significant in males), while brain mitochondrial respiratory capacity stays largely intact and oxidative phosphorylation genes rise.

SHADES, a deep learning framework, distinguishes evolutionary processes like neutrality, selection, and introgression using haplotype data from humans, outperforming existing methods.

The paper develops an automated high-content imaging workflow to quantify synapse loss associated with amyloid beta plaques in mouse brains, finding that large cored plaques primarily drive synapse loss.

This paper presents the genome of Braarudosphaera bigelowii, revealing genomic and metabolic adaptations associated with its symbiotic nitrogen-fixing organelle.

This study examines how desmin mutations affect filament assembly and aggregation, finding that specific mutations disrupt filament maturation and lead to distinct aggregation pathways.

Fission yeast Fss1, a PQ-loop membrane protein, acts in diploids to build full-thickness, chitin-containing spore walls and within spores to maintain vacuole morphology and timely germination.

This study investigates how iron levels affect Leishmania parasite growth, oxidative stress, and infectivity in macrophages, showing that optimal iron promotes survival while excess or deficiency causes toxicity and reduced infectivity.

This study uses FLIM to reveal the complexity of photosymbiosis in Retaria by distinguishing chlorophyll autofluorescence from FISH signals in environmental samples.

The paper evaluates parameter recoverability in cardiovascular LPN inference using a probabilistic neural framework, showing that accurate hemodynamic prediction does not guarantee correct parameter recovery.

This study identifies c-MYC as a non-canonical origin licensing accelerator, showing it increases licensing speed through TRRAP/GCN5 and histone H1 eviction, particularly in heterochromatin.

The paper develops a transcriptome-based framework to predict pathway dependency in HNSCC using Hallmark features, finding HPV+ tumors show higher dependency in seven pathways.