Jeanette Gowen Cook

This study identifies c-MYC as a non-canonical origin licensing accelerator, showing it increases licensing speed through TRRAP/GCN5 and histone H1 eviction, particularly in heterochromatin.

ELDR-Glo is a fluorescent biosensor that estimates relative cell age and quiescence depth, functioning in both live and fixed cells.

This study identifies USP37 as a deubiquitinase that prevents premature replisome disassembly by deubiquitinating MCM7, ensuring genome stability and normal cell cycle progression.

The paper shows that ecDNA allows tumors to adapt rapidly by maintaining a spectrum of gene expression levels across cells, rather than relying on clonal expansion.

This paper shows APC/C activity is essential to maintain CDK4/6 inhibitor-induced arrest by preventing premature S phase entry through degradation of cyclin A.

The paper introduces a novel PIP-FUCCI reporter to study endothelial cell cycle stages in postnatal retinal vessels and identifies G2 stalling in tip cells.

This study identifies G9a's noncanonical role in promoting translation of genes involved in hyperinflammation and lymphopenia in COVID-19, revealing therapeutic targets that counteract viral effects.

This study identifies a CHD4 missense mutation causing ventricular noncompaction by repressing ADAMTS1-mediated trabeculation cessation in mice and humans.

The paper quantifies MCM loading dynamics in euchromatin and heterochromatin during G1 phase, revealing differential rates and consequences for genome stability.

This study identifies bi-allelic MCM10 mutations causing telomere shortening, immune dysfunction, and cardiomyopathy by impairing DNA replication and telomerase activity.

The paper identifies a phosphorylation mechanism that inhibits Cdt1 to prevent re-replication in G2 phase and shows dephosphorylation reactivates Cdt1 in G1 phase.

The paper quantifies cell cycle phase durations in human cells and finds they are memoryless and uncoupled, with a mathematical model explaining their independence and potential coupling under dysfunction.

The paper investigates Cdt1 variants associated with Meier-Gorlin syndrome and a Drosophila allele to uncover their effects on MCM loading, Cyclin/CDK interactions, and genome replication.

The Cell Cycle Browser allows users to visualize, simulate, and perturb cell cycle progression using real-time reporter data from human cells.

This study examines how DNA damage checkpoints affect cell cycle phase transitions, revealing phase-specific differences in checkpoint sensitivity and cell fate outcomes.