Discover, rate, and discuss biology preprints.

Pose is a Python library for molecular structure manipulation that handles chirality and matches existing tools in energy and docking accuracy.

This study identifies DIRAS3 as a tumor suppressor that inhibits diverse oncogenic KRAS variants through a specific inhibitory interface, with a mimetic showing broad suppression of KRAS-driven signaling.

The paper maps transcription factor effector domains in plants and compares their function across eukaryotes, revealing conserved and lineage-specific regulatory principles.

This study compares N-acetylglucosamine (GlcNAc) and glucosamine hydrochloride (GlcN·HCl) in a rat model of knee osteoarthritis, finding GlcNAc more effective in reducing inflammation, cartilage degradation, and promoting DNA repair.

This study shows that heart/foregut-like structures form from human pluripotent stem cells, developing into vascularized cardiac organoids with multiple cell types.

LiverHomo integrates human liver scRNA-seq data with PPI and cell-cell communication networks to provide an interactive resource for exploring liver health and disease.

This study identifies multiple non-redundant functions of lipopolysaccharide (LPS) in Gram-negative bacteria, showing it is essential for envelope mechanics, membrane biogenesis, and efflux pump activity.

The paper uses MRI and transcriptomic data from a GD3 synthase-deficient mouse model to identify molecular correlates of brain structural differences.

The paper develops a prediction-interval framework to identify outlier control cohorts in lifespan studies using data from the National Institute on Aging Interventions Testing Program.

The paper shows RNA m6A modifications coordinate with de novo DNA methylation to establish heritable epigenetic silencing in human cells.

The paper investigates chromatic acclimation in two Synechococcus species, finding that WH8109 lacks detectable CA4 despite having an intact CA4-B genomic island.

The paper shows that manipulating cortical activity during sleep deprivation prevents ER stress responses while increasing sleep pressure markers.

Localis-REX identifies locale-specific reactive electrophilic metabolite responsive proteins in C. elegans and cultured cells using light-triggered uncaging and proteomics or functional readouts.

This paper measures blood velocity response timing across the vascular network using dynamic PC-fMRA, showing arterial and venous responses with distinct temporal delays.

This study identifies multivalent ubiquitin recognition as a regulator of Tau self-assembly stages, showing ubiquitin's role in modulating condensate formation and aggregation.

The paper studies AMR dissemination in Arabian Sea coastal waters, identifying diverse plasmid replicons and clinically relevant antibiotic resistance genes linked to anthropogenic stressors.

This study identifies 38 expression-modulating variants associated with neurodevelopmental disorders and links them to neurodevelopmental transcriptional programs using MPRA and CROP-seq.

This paper evaluates residue-level attributions in protein language models using synthetic fitness landscapes and identifies interventions that improve attribution accuracy.

The paper shows humans can learn counterintuitive goals but with initial costs, supported by fast revaluation and slow value updating mechanisms.

This study shows that deleting LRP1 in smooth muscle cells causes infrarenal aortic aneurysms in mice, which can be mitigated by inhibiting hepatocyte-derived angiotensinogen.