Michael Franklin

This study shows that PAI-1 deficiency leads to early cardiac hemorrhage and fibrosis under hemodynamic stress, with mutations in the protease-inhibitory domain causing similar pathology.

This study shows that deleting LRP1 in smooth muscle cells causes infrarenal aortic aneurysms in mice, which can be mitigated by inhibiting hepatocyte-derived angiotensinogen.

This study shows that Angiotensin II exacerbates mitral valve and left atrial pathology in Fbn1C1041G/+ mice, while AGT inhibition does not alter the phenotype.

This study shows that deleting angiotensinogen in hepatocytes protects mice from diet-induced metabolic disorders even under thermoneutral conditions that mimic human metabolism.

This study shows that AngII infusion worsens aortic pathology in Fbn1C1041G/+ mice, leading to aortic rupture and branch aneurysms.

This study investigates whether metformin reduces AngII-induced aortic aneurysms in LDLR-/- mice and finds it does not.

This study shows that cilostazol and sildenafil do not prevent BAPN-induced thoracic aortopathy in mice.

This study shows that deleting megalin in renal proximal tubule cells does not reduce atherosclerosis but causes tubulointerstitial nephritis in male mice fed a Western diet.

This study shows that BAPN induces distinct aortic pathologies in the ascending and descending thoracic aortas of young mice, with different structural and cellular changes in each region.

This study shows that renal angiotensinogen in nonhuman primates is mainly derived from the liver, as evidenced by reduced renal AGT levels after liver-specific AGT inhibition.