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Concussion decreases brain signal variability

This study shows that concussion reduces BOLD signal variability in specific brain networks, linking it to symptom severity and cognitive decline.

Neurons entrain and shape an intrinsic arteriole rhythm that distributes blood across the cortical mantle

The paper shows neurons entrain an intrinsic arteriole rhythm, shaping blood distribution and vascular responses through frequency-dependent mechanisms.

TailEnrich enables discovery of dysregulated genes through disease sample enrichment testing

TailEnrich identifies dysregulated genes in patient subsets by testing expression distribution tails, outperforming DESeq2 and edgeR in simulated data and uncovering novel genes in Alzheimer's disease.

Asymmetric division and polar growth define a non-canonical cell cycle in Bradyrhizobium.

This study describes the asymmetric cell division and polar growth in Bradyrhizobium, revealing a unique cell cycle program with distinct nucleoid dynamics and chromosome organization.

Global repression of mesenchymal genes in epithelial cells by the histone demethylase LSD1

This study shows LSD1 represses mesenchymal genes in epithelial cells, maintaining epithelial identity, and challenges the therapeutic use of LSD1 inhibition for EMT control.

Residual barcode-like sequences and barcode-associated artifacts after Dorado and Barbell preprocessing of metagenomic reads

The paper evaluates Dorado and Barbell preprocessing tools for metagenomic reads, finding Barbell reduces barcode-like sequences more effectively while retaining most reads.

Satellite cell glucocorticoid receptor restrains myogenic commitment without mediating the effects of therapeutic glucocorticoids on muscle repair

This study shows that satellite cell glucocorticoid receptor (GR) maintains quiescence but does not mediate therapeutic GC effects on muscle repair, highlighting the importance of treatment timing and context.

Seed Amplification Assay-Based Detection of Alpha-Synuclein Aggregates Outperforms Immunohistochemical Analysis in the Intestinal Mucosal Biopsies of Parkinson's Disease and Multiple System Atrophy Participants

This study compares a seed amplification assay for alpha-synuclein aggregates with immunohistochemistry in intestinal biopsies of Parkinson's disease and multiple system atrophy patients, finding the assay detects aggregates more frequently and with higher specificity.

Secondary growth in the tomato stem is suppressed by the flowering regulators FUL2 and STM3

This study identifies FUL2 and STM3 as repressors of secondary growth in tomato stems, showing their role in limiting xylem accumulation during stem development.

Temperature-dependent Fano resonance in Microtubules and Tubulin investigated with Spontaneous Raman Spectroscopy

The paper measures Raman spectra of microtubules and tubulin at various temperatures to investigate Fano resonance asymmetry in molecular bond vibrations.

Evolutionary dynamics of the pan-centromere architecture in oaks

The paper analyzes centromere evolution in oaks, showing lineage-specific expansion of QuCEN146 satellite drives turnover, while LTR-rich centromeres show low polymorphism due to suppressed recombination.

Starve, stress, and mate: Activation of the CCAAT-Binding complex overrides sterility of mating-type heterozygous Candida albicans

The paper identifies the CCAAT-binding complex (CBC) as a key regulator that overrides genetic sterility in Candida albicans by integrating environmental stress signals to enable mating.

Modeling circadian rhythm splitting under chronic light and the asymmetric transition kinetics between lighting conditions

The paper develops a biophysical model of the SCN to explain circadian rhythm splitting under chronic light and shows how E/I balance and chloride cotransporter dynamics drive this behavior.

Quantum Entanglement as a Physical Determinant of Genomic Instability in TP53

The paper explores whether quantum entanglement, measured via von Neumann Entropy, influences TP53 mutation patterns, finding elevated entropy at known mutational hotspots but cautioning about limited validation.

Residual Hearing Loss After Chronic Cochlear Implantation in Guinea Pigs is Primarily Conductive

This study identifies middle ear dysfunction as the primary cause of residual hearing loss in chronically implanted guinea pigs, suggesting a conductive mechanism.

Druggable CSNK2A1-MeCP2 regulatory axis links Okur-Chung neurodevelopmental syndrome with MECP2-related disorders

The paper identifies a druggable CSNK2A1-MeCP2 regulatory axis linking Okur-Chung neurodevelopmental syndrome with MECP2-related disorders through CRISPR screens and mouse models.

Hybrid RY-mers increase aDNA alignment sensitivity

This paper introduces hybrid RY-mers to improve aDNA alignment sensitivity and efficiency, showing higher accuracy and reduced runtime compared to existing methods.

Metabolites cross the membrane, the transcriptome does not follow: co-localization is required for the cyanobacterial response to a yeast partner

This study shows that cyanobacteria respond to yeast partners only when co-localized, not just through metabolite exchange.

Integrative Multiomics Analysis of the Angiogenesis-EMT Interface in Head and Neck Squamous Cell Carcinoma

This study identifies coordinated angiogenesis-EMT gene programs in OSCC using multi-omic analysis and validates candidate genes through external datasets and protein-level confirmation.

Visual surfaceomics reveals the substrate-scavenging cell surface of Asgard archaea

This study identifies surface proteins in Asgard archaea using visual surfaceomics, revealing a peptidophilic cell surface involved in peptide capture and symbiotic interactions.